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    pigo-1 GPI ethanolamine phosphate transferase 3 [ Caenorhabditis elegans ]

    Gene ID: 172285, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pigo-1
    Official Full Name
    GPI ethanolamine phosphate transferase 3
    Primary source
    WormBase:WBGene00016159
    Locus tag
    CELE_C27A12.9
    See related
    AllianceGenome:WB:WBGene00016159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 2. Orthologous to human PIGO (phosphatidylinositol glycan anchor biosynthesis class O). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pigo-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    18
    Sequence:
    Chromosome: I; NC_003279.8 (6061732..6068040, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene E3 ubiquitin-protein ligase ari-1.1 Neighboring gene Methyl-CpG binding protein 2/3 C-terminal domain-containing protein Neighboring gene Histone H1 Neighboring gene Treslin STD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PIGN prevents protein aggregation in the endoplasmic reticulum independently of its function in the GPI synthesis. Ihara S, et al. J Cell Sci, 2017 Feb 1. PMID 27980068
    2. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    3. An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans. Meissner B, et al. PLoS Genet, 2009 Jun. PMID 19557190, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI ethanolamine phosphate transferase 3
    NP_491750.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6061732..6068040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059349.7 → NP_491750.3  GPI ethanolamine phosphate transferase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491750.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01966
      Conserved Domains (1) summary
      cd16023
      Location:52 → 319
      GPI_EPT_3; GPI ethanolamine phosphate transferase 3, PIG-O
    Nucleotide Protein
    Heading Accession and Version

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