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    cnep-1 CTD nuclear envelope phosphatase 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 185802, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cnep-1
    Official Full Name
    CTD nuclear envelope phosphatase 1 homolog
    Primary source
    WormBase:WBGene00018474
    Locus tag
    CELE_F45E12.1
    See related
    AllianceGenome:WB:WBGene00018474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in nuclear membrane reassembly and regulation of nuclear division. Located in nuclear envelope. Is expressed in intestine and pharynx. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cnep-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (7310348..7313795)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Cullin-4 Neighboring gene B-related factor 1 Neighboring gene 60S ribosomal protein L23;Large ribosomal subunit protein uL14m Neighboring gene Neuropeptide-Like Protein Neighboring gene Uncharacterized protein Neighboring gene Amino acid transporter transmembrane domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatial regulation of phospholipid synthesis within the nuclear envelope domain of the endoplasmic reticulum. Bahmanyar S. Nucleus, 2015. PMID 25671705, Free PMC Article
    2. Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. Penfield L, et al. J Cell Biol, 2020 May 4. PMID 32271860, Free PMC Article
    3. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. Siniossoglou S, et al. J Biol Chem, 2000 Jun 23. PMID 10777497
    4. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Bahmanyar S, et al. Genes Dev, 2014 Jan 15. PMID 24449268, Free PMC Article
    5. A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans. Qadota H, et al. Mol Biol Cell, 2008 Jun. PMID 18337465, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear envelope organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear membrane reassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Nem1-Spo7 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CTD nuclear envelope phosphatase 1 homolog
    NP_001254123.1
    • Confirmed by transcript evidence
    NP_001379752.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7310348..7313795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393116.1 → NP_001379752.1  CTD nuclear envelope phosphatase 1 homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1ZUW4, Q20432
      Conserved Domains (1) summary
      TIGR02251
      Location:57 → 225
      HIF-SF_euk; Dullard-like phosphatase domain

    2. NM_001267194.3 → NP_001254123.1  CTD nuclear envelope phosphatase 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254123.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20432
      Conserved Domains (1) summary
      TIGR02251
      Location:87 → 255
      HIF-SF_euk; Dullard-like phosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20432.1

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