hat-1 Histone acetyltransferase type B catalytic subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hat-1
Official Full Name: Histone acetyltransferase type B catalytic subunit
Primary source: WormBase:WBGene00044069
Locus tag: CELE_M03C11.4
See related: AllianceGenome:WB:WBGene00044069
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone H4 acetyltransferase activity. Predicted to be involved in subtelomeric heterochromatin formation. Predicted to be located in chromosome, telomeric region and nucleus. Is expressed in coelomocyte and germ line. Orthologous to human HAT1 (histone acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hat-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (10405248..10407248, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RbAp46/48LIN-53 and HAT-1 are required for initial CENP-AHCP-3 deposition and de novo holocentromere formation on artificial chromosomes in Caenorhabditis elegans embryos.
Title: RbAp46/48LIN-53 and HAT-1 are required for initial CENP-AHCP-3 deposition and de novo holocentromere formation on artificial chromosomes in Caenorhabditis elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M03C11.4 (e-PCR)
- UniSTS:307813

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in subtelomeric heterochromatin formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Histone acetyltransferase type B catalytic subunit

NP_499296.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10405248..10407248 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066895.4 → NP_499296.2 Histone acetyltransferase type B catalytic subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499296.2

Status: REVIEWED

UniProtKB/TrEMBL

Q21484

Conserved Domains (1) summary

pfam10394
Location:15 → 171

Hat1_N; Histone acetyl transferase HAT1 N-terminus