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    lpd-2 LiPid Depleted [ Caenorhabditis elegans ]

    Gene ID: 172320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lpd-2
    Official Full Name
    LiPid Depleted
    Primary source
    WormBase:WBGene00003059
    Locus tag
    CELE_C48E7.3
    See related
    AllianceGenome:WB:WBGene00003059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in filopodium. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in nervous system. Orthologous to human NGDN (neuroguidin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lpd-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (6253701..6254947)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Olfactomedin-like domain-containing protein Neighboring gene CCAAT/enhancer-binding protein homolog 2 Neighboring gene DNA-directed RNA polymerase III subunit RPC3 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage. Ling J, et al. Nutr Metab (Lond), 2017. PMID 28261316, Free PMC Article
    2. C elegans: a model for exploring the genetics of fat storage. McKay RM, et al. Dev Cell, 2003 Jan. PMID 12530969, Free PMC Article
    3. IRE-1 and HSP-4 contribute to energy homeostasis via fasting-induced lipases in C. elegans. Jo H, et al. Cell Metab, 2009 May. PMID 19416714
    4. Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans. Soukup EM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36063055, Free PMC Article
    5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LiPid Depleted
    NP_491806.2
    • Product from WormBase gene class lpd;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6253701..6254947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059405.7 → NP_491806.2  LiPid Depleted [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491806.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG68
      Conserved Domains (1) summary
      pfam04000
      Location:13 → 91
      Sas10_Utp3; Sas10/Utp3/C1D family
    Nucleotide Protein
    Heading Accession and Version

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