ipla-1 Intracellular phospholipase A1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ipla-1
Official Full Name: Intracellular phospholipase A1
Primary source: WormBase:WBGene00019747
Locus tag: CELE_M03A1.6
See related: AllianceGenome:WB:WBGene00019747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity; phospholipase activity; and phospholipid binding activity. Involved in glycerophospholipid metabolic process; regulation of asymmetric cell division; and regulation of protein localization. Located in cytosol; endoplasmic reticulum; and nucleus. Part of phosphatase complex. Is expressed in several structures, including arcade cell; excretory cell; pharyngeal-intestinal valve; rectum; and reproductive system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 28. Orthologous to human DDHD1 (DDHD domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ipla-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 12

Sequence:: Chromosome: II; NC_003280.10 (4590939..4601356, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abnormal glycerophospholipid metabolism leading to defective embryonic development could be attributed to the increased activity of calcium-independent phospholipase A2 (iPLA) in G6PD-deficient embryos. This notion is further supported by the fact that the suppression of multiple iPLAs by genetic manipulation partially rescued the embryonic defects in G6PD-deficient embryos.
Title: Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism.
membrane composition and the presence of nucleotides play key roles in recruiting and modulating GVIA-iPLA(2) activity in cells
Title: Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform.
Study identified acl-8, -9, and -10, which are closely related to each other, and ipla-1 as strong candidates for genes involved in fatty acid remodeling at the sn-1 position of phosphatidylinositol.
Title: Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F35D11.5 (e-PCR)
- UniSTS:316716

F35D11.6 (e-PCR)
- UniSTS:316717

M03A1.6 (e-PCR)
- UniSTS:311972

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium-independent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A1 activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: Intracellular phospholipase A1

NP_001040793.1

Confirmed by transcript evidence

NP_001040794.1

Confirmed by transcript evidence

NP_001300574.1

Confirmed by transcript evidence

NP_001367816.1

Confirmed by transcript evidence

NP_001367817.1

Confirmed by transcript evidence

NP_740976.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4590939..4601356 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170979.6 → NP_740976.1 Intracellular phospholipase A1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740976.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21478

Conserved Domains (1) summary

pfam02862
Location:492 → 751

DDHD; DDHD domain
NM_001381395.3 → NP_001367816.1 Intracellular phospholipase A1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam02862
Location:480 → 739

DDHD; DDHD domain
NM_001381394.1 → NP_001367817.1 Intracellular phospholipase A1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AU10, G4SGS5, G4SGU1, G5EE61, G5EEM9, G8JYA8, Q21478, Q8WQE0

Conserved Domains (1) summary

pfam02862
Location:567 → 826

DDHD; DDHD domain
NM_001047329.4 → NP_001040794.1 Intracellular phospholipase A1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040794.1

Status: REVIEWED

UniProtKB/TrEMBL

G8JYA8

Conserved Domains (1) summary

pfam02862
Location:504 → 763

DDHD; DDHD domain
NM_001047328.5 → NP_001040793.1 Intracellular phospholipase A1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040793.1

Status: REVIEWED

UniProtKB/TrEMBL

G4SGU1

Conserved Domains (1) summary

pfam02862
Location:506 → 765

DDHD; DDHD domain
NM_001313645.3 → NP_001300574.1 Intracellular phospholipase A1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AU10

Conserved Domains (1) summary

pfam02862
Location:395 → 654

DDHD; DDHD domain