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    sea-2 Signal element on autosome protein 2 [ Caenorhabditis elegans ]

    Gene ID: 173738, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sea-2
    Official Full Name
    Signal element on autosome protein 2
    Primary source
    WormBase:WBGene00004751
    Locus tag
    CELE_K10G6.3
    See related
    AllianceGenome:WB:WBGene00004751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables double-stranded RNA binding activity and single-stranded RNA binding activity. Involved in several processes, including determination of adult lifespan; regulation of gene expression; and response to heat. Located in cytoplasm and nucleus. Is expressed in several structures, including anal region; intestinal cell; neurons; pharyngeal muscle cell; and seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sea-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (3950377..3972140)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene SPK domain-containing protein Neighboring gene C2H2-type domain-containing protein;DUF659 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Cilia- and flagella-associated protein 157 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular antagonism between X-chromosome and autosome signals determines nematode sex. Farboud B, et al. Genes Dev, 2013 May 15. PMID 23666922, Free PMC Article
    2. Identification of muscle-specific regulatory modules in Caenorhabditis elegans. Zhao G, et al. Genome Res, 2007 Mar. PMID 17284674, Free PMC Article
    3. The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans. Huang X, et al. Development, 2011 May. PMID 21471153
    4. Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans. Zhang P, et al. EMBO Rep, 2013 Jun. PMID 23619095, Free PMC Article
    5. Somatic sex determination. Zarkower D. WormBook, 2006 Feb 10. PMID 18050479, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of development, heterochronic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sex-chromosome dosage compensation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Signal element on autosome protein 2
    NP_001293473.1
    • Confirmed by transcript evidence
    NP_001293474.1
    • Confirmed by transcript evidence
    NP_001293475.1
    • Confirmed by transcript evidence
    NP_001300568.1
    • Confirmed by transcript evidence
    NP_001300569.1
    • Confirmed by transcript evidence
    NP_001300570.1
    • Confirmed by transcript evidence
    NP_001300571.1
    • Confirmed by transcript evidence
    NP_001300572.1
    • Partially confirmed by transcript evidence
    NP_001300573.1
    • Confirmed by transcript evidence
    NP_001364835.1
    • Confirmed by transcript evidence
    NP_001364836.1
    • Partially confirmed by transcript evidence
    NP_001364838.1
    • Partially confirmed by transcript evidence
    NP_001368182.1
    • Confirmed by transcript evidence
    NP_001368183.1
    • Confirmed by transcript evidence
    NP_001368506.1
    • Partially confirmed by transcript evidence
    NP_001368517.1
    • Confirmed by transcript evidence
    NP_001368518.1
    • Confirmed by transcript evidence
    NP_001368519.1
    • Confirmed by transcript evidence
    NP_001368520.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3950377..3972140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377774.1 → NP_001364835.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam13894
      Location:1274 → 1297
      zf-C2H2_4; C2H2-type zinc finger

    2. NM_001377773.3 → NP_001364838.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      PHA03247
      Location:1163 → 1366
      PHA03247; large tegument protein UL36; Provisional
      pfam13894
      Location:1129 → 1152
      zf-C2H2_4; C2H2-type zinc finger

    3. NM_001377772.3 → NP_001364836.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0K3AQV3, A0A0K3AR28, A0A0K3AR30, A0A0K3ARE6, A0A0K3ARN1, A0A0K3ARN6, A0A0K3AU01, A0A0K3AU05, A0A0K3AUE4, A0A0K3AUM9, A0A0K3AUN5, A0A0K3AWR2, A0A0K3AWZ4, A0A0K3AX01, S6EZL2, S6F519, S6FCX8, S6FMY4, S6FWN6
      Conserved Domains (2) summary
      PRK12323
      Location:1306 → 1510
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam13894
      Location:1274 → 1297
      zf-C2H2_4; C2H2-type zinc finger

    4. NM_001381374.1 → NP_001368506.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      PRK12323
      Location:1161 → 1365
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam13894
      Location:1129 → 1152
      zf-C2H2_4; C2H2-type zinc finger

    5. NM_001306546.2 → NP_001293475.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293475.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FWN6
      Conserved Domains (1) summary
      pfam13894
      Location:1178 → 1201
      zf-C2H2_4; C2H2-type zinc finger

    6. NM_001306544.2 → NP_001293473.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZL2
      Conserved Domains (1) summary
      PRK12323
      Location:1210 → 1414
      PRK12323; DNA polymerase III subunit gamma/tau

    7. NM_001306545.3 → NP_001293474.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FMY4
      Conserved Domains (1) summary
      PRK12323
      Location:1065 → 1269
      PRK12323; DNA polymerase III subunit gamma/tau

    8. NM_001381375.1 → NP_001368517.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam13894
      Location:1033 → 1056
      zf-C2H2_4; C2H2-type zinc finger

    9. NM_001313639.3 → NP_001300568.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARN1
      Conserved Domains (2) summary
      PRK12323
      Location:1130 → 1334
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam13894
      Location:1098 → 1121
      zf-C2H2_4; C2H2-type zinc finger

    10. NM_001313640.3 → NP_001300569.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU05
      Conserved Domains (1) summary
      PRK12323
      Location:985 → 1189
      PRK12323; DNA polymerase III subunit gamma/tau

    11. NM_001381376.1 → NP_001368518.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam13894
      Location:1098 → 1121
      zf-C2H2_4; C2H2-type zinc finger

    12. NM_001381377.1 → NP_001368519.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam13894
      Location:953 → 976
      zf-C2H2_4; C2H2-type zinc finger

    13. NM_001313643.3 → NP_001300572.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX01
      Conserved Domains (2) summary
      PRK12323
      Location:968 → 1172
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam13894
      Location:936 → 959
      zf-C2H2_4; C2H2-type zinc finger

    14. NM_001313642.3 → NP_001300571.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUN5
      Conserved Domains (1) summary
      PHA03247
      Location:825 → 1028
      PHA03247; large tegument protein UL36; Provisional

    15. NM_001381378.1 → NP_001368182.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam13894
      Location:936 → 959
      zf-C2H2_4; C2H2-type zinc finger

    16. NM_001381379.1 → NP_001368520.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam13894
      Location:791 → 814
      zf-C2H2_4; C2H2-type zinc finger

    17. NM_001313644.3 → NP_001300573.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARN6
      Conserved Domains (2) summary
      PHA03247
      Location:391 → 602
      PHA03247; large tegument protein UL36; Provisional
      pfam13894
      Location:407 → 430
      zf-C2H2_4; C2H2-type zinc finger

    18. NM_001381380.1 → NP_001368183.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam13894
      Location:407 → 430
      zf-C2H2_4; C2H2-type zinc finger

    19. NM_001313641.3 → NP_001300570.1  Signal element on autosome protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR30
      Conserved Domains (1) summary
      smart00225
      Location:18 → 104
      BTB; Broad-Complex, Tramtrack and Bric a brac
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0K3AUE4.1

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