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    paf-2 Platelet-activating factor acetylhydrolase homolog 2 [ Caenorhabditis elegans ]

    Gene ID: 180704, updated on 9-Dec-2024

    Summary

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    Official Symbol
    paf-2
    Official Full Name
    Platelet-activating factor acetylhydrolase homolog 2
    Primary source
    WormBase:WBGene00003907
    Locus tag
    CELE_C52B9.7
    See related
    AllianceGenome:WB:WBGene00003907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity. Involved in lipid catabolic process and morphogenesis of embryonic epithelium. Predicted to be located in cytosol and endoplasmic reticulum membrane. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII) and PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See paf-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (4291475..4294352, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ETS domain-containing protein Neighboring gene ncRNA Neighboring gene ETS class transcription factor Neighboring gene Choline kinase A2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans. Inoue T, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15340150, Free PMC Article
    2. Proton Microbeam Targeted Irradiation of the Gonad Primordium Region Induces Developmental Alterations Associated with Heat Shock Responses and Cuticle Defense in Caenorhabditis elegans. Beaudier P, et al. Biology (Basel), 2023 Oct 27. PMID 37997971, Free PMC Article
    3. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
    4. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAF-AH (II) is predominantly expressed in epithelial cells of C. elegans. This study demonstrates that PAF-AH (II) is essential for epithelial morphogenesis.
      Title: Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Platelet-activating factor acetylhydrolase homolog 2
    NP_001379717.1
    • Partially confirmed by transcript evidence
    NP_741768.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4291475..4294352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171668.10 → NP_741768.1  Platelet-activating factor acetylhydrolase homolog 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22943
      Conserved Domains (1) summary
      pfam03403
      Location:4 → 372
      PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

    2. NM_001392759.1 → NP_001379717.1  Platelet-activating factor acetylhydrolase homolog 2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl21494
      Location:4 → 186
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22943.2

    Gene LinkOut

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