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    Y39G8B.2 NADP-dependent oxidoreductase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y39G8B.2
    Official Full Name
    NADP-dependent oxidoreductase domain-containing protein
    Primary source
    WormBase:WBGene00012723
    Locus tag
    CELE_Y39G8B.2
    See related
    AllianceGenome:WB:WBGene00012723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aldose reductase (NADPH) activity. Predicted to be involved in small molecule metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y39G8B.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (13973852..13976221, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NADP-dependent oxidoreductase domain-containing protein
    NP_496926.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13973852..13976221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064525.7 → NP_496926.1  NADP-dependent oxidoreductase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2J5
      Conserved Domains (1) summary
      cd19071
      Location:15 → 295
      AKR_AKR1-5-like; AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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