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    lab-1 Long arms of the bivalent protein 1 [ Caenorhabditis elegans ]

    Gene ID: 182160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lab-1
    Official Full Name
    Long arms of the bivalent protein 1
    Primary source
    WormBase:WBGene00007278
    Locus tag
    CELE_C03D6.6
    See related
    AllianceGenome:WB:WBGene00007278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein phosphatase 1 binding activity. Involved in meiotic sister chromatid cohesion and regulation of protein localization to nucleus. Located in condensed chromosome and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lab-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (9657012..9658023, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box associated domain-containing protein Neighboring gene DeHydrogenases, Short chain Neighboring gene F-box domain-containing protein Neighboring gene protein-disulfide reductase Neighboring gene putative histone chaperone asf-1-like protein Neighboring gene Aa_trans domain-containing protein Neighboring gene Nuclear pore complex protein 14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing. Billmyre KK, et al. PLoS Genet, 2019 Mar. PMID 30921322, Free PMC Article
    2. Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis. Ferrandiz N, et al. Nat Commun, 2018 Feb 26. PMID 29483514, Free PMC Article
    3. Spatial Transcriptomics of Nematodes Identifies Sperm Cells as a Source of Genomic Novelty and Rapid Evolution. Rödelsperger C, et al. Mol Biol Evol, 2021 Jan 4. PMID 32785688, Free PMC Article
    4. Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation. Altendorfer E, et al. Curr Biol, 2020 Apr 6. PMID 32142707, Free PMC Article
    5. LAB-1 antagonizes the Aurora B kinase in C. elegans. de Carvalho CE, et al. Genes Dev, 2008 Oct 15. PMID 18923084, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dynamic recruitment of LAB proteins senses meiotic chromosome axis differentiation in C. elegans.
      Title: The dynamic recruitment of LAB proteins senses meiotic chromosome axis differentiation in C. elegans.
    2. LAB-1 depletion reduces pairing and sister chromatid cohesion.
      Title: LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Long arms of the bivalent protein 1
    NP_492566.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9657012..9658023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060165.7 → NP_492566.1  Long arms of the bivalent protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17604, Q17605
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17604.2

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