lst-1 Lateral signaling target 1 protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lst-1
Official Full Name: Lateral signaling target 1 protein
Primary source: WormBase:WBGene00003083
Locus tag: CELE_T22A3.3
See related: AllianceGenome:WB:WBGene00003083
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables G-protein alpha-subunit binding activity. Involved in regulation of gene expression. Is expressed in several structures, including accessory cell; amphid neurons; germ line; gonad; and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lst-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (10588501..10590465)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LST-1 is a bifunctional regulator that feeds back on Notch-dependent transcription to regulate C. elegans germline stem cells.
Title: LST-1 is a bifunctional regulator that feeds back on Notch-dependent transcription to regulate C. elegans germline stem cells.
Analysis suggests that the function of the primary response genes lst-1 and sygl-1 can account for the glp-1 dependent peak protein accumulation of FBF-2, which promotes the stem cell fate and, in part, for the spatial restriction of elevated LAG-1 accumulation to the stem cell region.
Title: GLP-1 Notch-LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1.
Study demonstrates that LST-1 self-renewal activity resides within a predicted disordered region that harbors two KXXL motifs. It find that the KXXL motifs mediate the binding of LST-1 to FBF, and that point mutations of these motifs abrogate LST-1 self-renewal activity. The LST-1-FBF partnership is therefore crucial to stem cell maintenance and is a key element in the FBF regulatory network
Title: The molecular basis of LST-1 self-renewal activity and its control of stem cell pool size.
LST-1 weakens FBF-2 binding affinity for short and long motifs, which may increase target selectivity.
Title: A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity.
our results support a model in which SYGL-1 and LST-1 form a repressive complex with FBF that is crucial for stem cell maintenance. We further propose that progression from a naive stem cell state to a state primed for differentiation relies on loss of SYGL-1 and LST-1, which in turn relieves FBF target RNAs from repression
Title: SYGL-1 and LST-1 link niche signaling to PUF RNA repression for stem cell maintenance in Caenorhabditis elegans.
lst-1 and sygl-1 forge a critical link between Notch signaling and germ-line stem cell maintenance.
Title: Discovery of two GLP-1/Notch target genes that account for the role of GLP-1/Notch signaling in stem cell maintenance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T22A3.3 (e-PCR)
- UniSTS:308079

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed

General protein information

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Preferred Names: Lateral signaling target 1 protein

NP_001021628.2

Confirmed by transcript evidence

NP_001379446.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10588501..10590465

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026457.6 → NP_001021628.2 Lateral signaling target 1 protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P91820, Q564V2

UniProtKB/TrEMBL

Q86RT0
NM_001392939.1 → NP_001379446.1 Lateral signaling target 1 protein [Caenorhabditis elegans]

Status: REVIEWED