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    Y6B3B.9 C2H2-type domain-containing protein;TRAM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y6B3B.9
    Official Full Name
    C2H2-type domain-containing protein;TRAM domain-containing protein
    Primary source
    WormBase:WBGene00012393
    Locus tag
    CELE_Y6B3B.9
    See related
    AllianceGenome:WB:WBGene00012393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of Las1 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y6B3B.9 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (13734958..13751124, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene putative ceramide synthase lagr-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene inositol-phosphate phosphatase Neighboring gene S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Las1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein;TRAM domain-containing protein
    NP_001129801.1
    • Confirmed by transcript evidence
    NP_001252220.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13734958..13751124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265291.2 → NP_001252220.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1T1
      Conserved Domains (1) summary
      pfam04031
      Location:13 → 162
      Las1; Las1-like

    2. NM_001136329.4 → NP_001129801.1  TRAM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3KYB9
    Nucleotide Protein
    Heading Accession and Version

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