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    F46B6.5 LisH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F46B6.5
    Official Full Name
    LisH domain-containing protein
    Primary source
    WormBase:WBGene00009770
    Locus tag
    CELE_F46B6.5
    See related
    AllianceGenome:WB:WBGene00009770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F46B6.5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (9779611..9783069, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene UPF3 domain-containing protein Neighboring gene Hflx-type G domain-containing protein Neighboring gene Tr-type G domain-containing protein Neighboring gene Zinc finger protein ztf-7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
    2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LisH domain-containing protein
    NP_001023935.1
    • Confirmed by transcript evidence
    NP_001256137.1
    • Confirmed by transcript evidence
    NP_001256138.1
    • Confirmed by transcript evidence
    NP_505524.2
    • Confirmed by transcript evidence
    NP_872162.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9779611..9783069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182362.7 → NP_872162.2  LisH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872162.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4I7
      Conserved Domains (2) summary
      TIGR01622
      Location:433 → 527
      SF-CC1; splicing factor, CC1-like family
      pfam08513
      Location:34 → 58
      LisH

    2. NM_001269209.4 → NP_001256138.1  LisH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2B2
      Conserved Domains (2) summary
      TIGR01642
      Location:457 → 570
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam08513
      Location:34 → 58
      LisH

    3. NM_073123.5 → NP_505524.2  LisH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505524.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20453
      Conserved Domains (2) summary
      TIGR01642
      Location:457 → 570
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam08513
      Location:34 → 58
      LisH

    4. NM_001269208.3 → NP_001256137.1  LisH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L2B3
      Conserved Domains (2) summary
      TIGR01642
      Location:457 → 570
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam08513
      Location:34 → 58
      LisH

    5. NM_001028764.6 → NP_001023935.1  LisH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTV3
      Conserved Domains (2) summary
      TIGR01642
      Location:457 → 570
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam08513
      Location:34 → 58
      LisH
    Nucleotide Protein
    Heading Accession and Version

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