ceh-20 Homeobox protein ceh-20 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-20
Official Full Name: Homeobox protein ceh-20
Primary source: WormBase:WBGene00000443
Locus tag: CELE_F31E3.1
See related: AllianceGenome:WB:WBGene00000443
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cis-regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate specification; dopaminergic neuron differentiation; and positive regulation of mesodermal cell fate specification. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay. Orthologous to several human genes including PBX4 (PBX homeobox 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ceh-20 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (6979884..6981785)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ceh-20 is genetically required for the promoter activity of unc-62. Unc-62 & ceh-20 have overlapping expression patterns within and outside of the M lineage, & they share physical and regulatory interactions.
Title: Two Hox cofactors, the Meis/Hth homolog UNC-62 and the Pbx/Exd homolog CEH-20, function together during C. elegans postembryonic mesodermal development.
mls-2 might be a direct target of CEH-20 in the M lineage and the regulation of CEH-20 on mls-2 is likely Hox-independent
Title: Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20.
In the P11 lineage, a complex between MAB-5 and the Pbx homolog CEH-20 directly regulates transcription of the BH3 domain gene egl-1 to initiate programmed cell death.
Title: Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1.
Transcription factors LIN-39 and CEH-20, which function at the bottom of the RTK/Ras and Wnt pathways in vulval induction, serve as major integration sites in coordinating and transmitting signals to the LIN-12/Notch cascade to regulate vulval cell fates.
Title: Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F31E3.1 (e-PCR)
- UniSTS:310048

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior pattern specification	TAS Traceable Author Statement more info	PubMed
involved_in dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox protein ceh-20

NP_001022555.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6979884..6981785

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027384.7 → NP_001022555.1 Homeobox protein ceh-20 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022555.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41779

Conserved Domains (2) summary

cd00086
Location:189 → 250

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam03792
Location:6 → 187

PBC; PBC domain