cisd-3.1 Iron-binding zinc finger CDGSH type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cisd-3.1
Official Full Name: Iron-binding zinc finger CDGSH type domain-containing protein
Primary source: WormBase:WBGene00010909
Locus tag: CELE_M88.7
See related: AllianceGenome:WB:WBGene00010909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cisd-3.1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (4542881..4546014)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disrupting the function of the cisd genes resulted in various germline abnormalities including distal tip cell migration defects and a significant increase in the number of cell corpses within the adult germline. This work places the CISD family members as regulators of physiological germline programmed cell death acting through CED-13 and the core apoptotic machinery.
Title: The cisd gene family regulates physiological germline apoptosis through ced-13 and the canonical cell death pathway in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M88.3 (e-PCR)
- UniSTS:307825

M88.2 (e-PCR)
- UniSTS:316916

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein maturation by [2Fe-2S] cluster transfer	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Iron-binding zinc finger CDGSH type domain-containing protein

NP_497920.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

4542881..4546014

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065519.7 → NP_497920.3 Iron-binding zinc finger CDGSH type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497920.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3A1

Conserved Domains (2) summary

smart00704
Location:74 → 111

ZnF_CDGSH; CDGSH-type zinc finger. Function unknown

cl02748
Location:117 → 147

zf-CDGSH; Iron-binding zinc finger CDGSH type