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    gar-2 G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2 [ Caenorhabditis elegans ]

    Gene ID: 175893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gar-2
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2
    Primary source
    WormBase:WBGene00001518
    Locus tag
    CELE_F47D12.1
    See related
    AllianceGenome:WB:WBGene00001518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Located in axon. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gar-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (6309366..6320873)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Kelch repeat and BTB domain-containing protein F47D12.7 Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein;putative WD repeat-containing protein F47D12.9 Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three functional isoforms of GAR-2, a Caenorhabditis elegans G-protein-linked acetylcholine receptor, are produced by alternative splicing. Suh SJ, et al. Biochem Biophys Res Commun, 2001 Nov 16. PMID 11700045
    2. Metabotropic histamine receptors--nothing for invertebrates? Roeder T. Eur J Pharmacol, 2003 Apr 11. PMID 12679144
    3. Characterization of GAR-2, a novel G protein-linked acetylcholine receptor from Caenorhabditis elegans. Lee YS, et al. J Neurochem, 2000 Nov. PMID 11032868
    4. Novel actions of arecoline in the C. elegans motor circuit. McCulloch KA, et al. MicroPubl Biol, 2020 Jul 1. PMID 32666042, Free PMC Article
    5. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. Dittman JS, et al. J Neurosci, 2008 Jul 9. PMID 18614679, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, these results suggest decreased SMN leads to defective microRNA function via MEL-46 misregulation, followed by increased M2 muscarinic receptor expression, and neuronal dysfunction in Spinal Muscular Atrophy.
      Title: Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models.
    2. This study identify a muscarinic receptor (GAR-2) and the GABA(B) receptor dimer (GBB-1/2) that detect synaptically released ACh and GABA and regulate the locomotion.
      Title: Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled acetylcholine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled acetylcholine receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables G protein-coupled acetylcholine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled amine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to nitrogen compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of synaptic transmission, cholinergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein;Muscarinic acetylcholine receptor gar-2
    NP_001022593.1
    • Confirmed by transcript evidence
    NP_001022594.1
    • Confirmed by transcript evidence
    NP_001022596.1
    • Partially confirmed by transcript evidence
    NP_001022597.1
    • Confirmed by transcript evidence
    NP_001368076.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6309366..6320873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027423.7 → NP_001022594.1  Muscarinic acetylcholine receptor gar-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09388
      Conserved Domains (2) summary
      pfam00001
      Location:22 → 210
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:16 → 214
      7tm_4; Olfactory receptor

    2. NM_001379757.3 → NP_001368076.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ41, Q8MTW9
      Conserved Domains (3) summary
      cd15302
      Location:6 → 199
      7tmA_mAChR_GAR-2-like; muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
      cd14964
      Location:578 → 608
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:575 → 653
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001027422.5 → NP_001022593.1  Muscarinic acetylcholine receptor gar-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022593.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09388, Q09561, Q95WX7
      Conserved Domains (2) summary
      pfam00001
      Location:22 → 210
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:16 → 214
      7tm_4; Olfactory receptor

    4. NM_001027425.5 → NP_001022596.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ40
      Conserved Domains (2) summary
      cd14964
      Location:7 → 33
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:6 → 199
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. NM_001027426.5 → NP_001022597.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022597.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I7J8
      Conserved Domains (2) summary
      cd14964
      Location:248 → 278
      7tm_GPCRs; TM helix 6 [structural motif]
      cl28897
      Location:245 → 323
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09388.3

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