lec-1 32 kDa beta-galactoside-binding lectin;Galectin [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lec-1
Official Full Name: 32 kDa beta-galactoside-binding lectin;Galectin
Primary source: WormBase:WBGene00002264
Locus tag: CELE_W09H1.6
See related: AllianceGenome:WB:WBGene00002264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables galactoside binding activity. Located in collagen and cuticulin-based cuticle extracellular matrix. Orthologous to several human genes including LGALS9 (galectin 9) and LGALS9B (galectin 9B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lec-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (13195549..13199713)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galectins LEC-6 and LEC-1 recognize a chemically synthesized Galbeta1-4Fuc disaccharide unit.
Title: Caenorhabditis elegans galectins LEC-6 and LEC-1 recognize a chemically synthesized Galbeta1-4Fuc disaccharide unit which is present in Protostomia glycoconjugates.
crystallographic study of galectin LEC-1
Title: Crystallization and preliminary x-ray crystallographic analysis of galectin LEC-1 from Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W09H1.6 (e-PCR)
- UniSTS:319930

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables galactoside binding	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in collagen and cuticulin-based cuticle extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	HDA more info	PubMed

General protein information

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Preferred Names: 32 kDa beta-galactoside-binding lectin;Galectin

NP_001022405.1

Partially confirmed by transcript evidence

NP_001379224.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13195549..13199713

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393217.1 → NP_001379224.1 32 kDa beta-galactoside-binding lectin [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P36573

Conserved Domains (1) summary

cd00070
Location:151 → 277

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
NM_001027234.4 → NP_001022405.1 Galectin [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022405.1

Status: REVIEWED

UniProtKB/TrEMBL

O45904

Conserved Domains (1) summary

cd00070
Location:157 → 283

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...