U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    abts-1 Anion exchange protein [ Caenorhabditis elegans ]

    Gene ID: 172613, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    abts-1
    Official Full Name
    Anion exchange protein
    Primary source
    WormBase:WBGene00009920
    Locus tag
    CELE_F52B5.1
    See related
    AllianceGenome:WB:WBGene00009920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables chloride transmembrane transporter activity and solute:inorganic anion antiporter activity. Involved in several processes, including cholinergic synaptic transmission; regulation of GABAergic synaptic transmission; and response to serotonin. Predicted to be located in basolateral plasma membrane; lateral plasma membrane; and synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to several human genes including SLC4A10 (solute carrier family 4 member 10); SLC4A7 (solute carrier family 4 member 7); and SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See abts-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (8296917..8307566, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Casein kinase II subunit beta Neighboring gene Nuclear pore complex protein Nup85 Neighboring gene Meiotic spindle formation protein mei-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caenorhabditis elegans bicarbonate transporter ABTS-1 is involved in arsenite toxicity and cholinergic signaling. Liao VH, et al. Chem Res Toxicol, 2010 May 17. PMID 20423156
    2. An evolutionarily conserved switch in response to GABA affects development and behavior of the locomotor circuit of Caenorhabditis elegans. Han B, et al. Genetics, 2015 Apr. PMID 25644702, Free PMC Article
    3. Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans. Bellemer A, et al. EMBO J, 2011 May 4. PMID 21427702, Free PMC Article
    4. EOR-1 mediates non-cell autonomous regulation of abts-1 gene expression in HSNs​. Shinkai Y, et al. MicroPubl Biol, 2018 Jul 12. PMID 32550393, Free PMC Article
    5. Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans. Gürel G, et al. Genetics, 2012 Dec. PMID 23023001, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables secondary active transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables solute:inorganic anion antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to serotonin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Anion exchange protein
    NP_001129776.1
    • Confirmed by transcript evidence
    NP_001366789.1
    • Confirmed by transcript evidence
    NP_001367194.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8296917..8307566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136304.5 → NP_001129776.1  Anion exchange protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDF4, O61304
      Conserved Domains (3) summary
      TIGR00834
      Location:86 → 1049
      ae; anion exchange protein
      pfam00955
      Location:437 → 952
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:109 → 387
      Band_3_cyto; Band 3 cytoplasmic domain

    2. NM_001380825.2 → NP_001366789.1  Anion exchange protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC65, O61304
      Conserved Domains (1) summary
      TIGR00834
      Location:44 → 1007
      ae; anion exchange protein

    3. NM_001380826.1 → NP_001367194.1  Anion exchange protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3WFV9, O61304
      Conserved Domains (1) summary
      TIGR00834
      Location:86 → 1103
      ae; anion exchange protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools