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    smp-1 Sema domain-containing protein;Semaphorin-1A [ Caenorhabditis elegans ]

    Gene ID: 173351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smp-1
    Official Full Name
    Sema domain-containing protein;Semaphorin-1A
    Primary source
    WormBase:WBGene00004889
    Locus tag
    CELE_Y54E5B.1
    See related
    AllianceGenome:WB:WBGene00004889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including hermaphrodite distal tip cell; male-specific anatomical entity; non-striated muscle; somatic nervous system; and vulval cell. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia and progressive myoclonus epilepsy. Orthologous to several human genes including SEMA3B (semaphorin 3B); SEMA3C (semaphorin 3C); and SEMA6A (semaphorin 6A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (14807462..14815729)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BLOC-1-related complex subunit 8 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Mediator of RNA polymerase II transcription subunit 7 Neighboring gene Ubiquitin-conjugating enzyme E2 W

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An analysis of semaphorin-mediated cellular interactions in the Caenorhabditis elegans epidermis using the IR-LEGO single-cell gene induction system. Suzuki M, et al. Dev Growth Differ, 2024 Jun. PMID 38761018, Free PMC Article
    2. C. elegans PlexinA PLX-1 mediates a cell contact-dependent stop signal in vulval precursor cells. Liu Z, et al. Dev Biol, 2005 Jun 1. PMID 15936335
    3. Interaxonal interaction defines tiled presynaptic innervation in C. elegans. Mizumoto K, et al. Neuron, 2013 Feb 20. PMID 23439119, Free PMC Article
    4. Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg VE, et al. Development, 2002 May. PMID 11959817
    5. The transcription factor VAB-23 links vulval cell fate specification and morphogenesis. Pellegrino MW, et al. Worm, 2012 Jul 1. PMID 24058843, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Semaphorin-1 and netrin signal in parallel and permissively to position the male ray 1 sensillum in Caenorhabditis elegans.
      Title: Semaphorin-1 and netrin signal in parallel and permissively to position the male ray 1 sensillum in Caenorhabditis elegans.
    2. Data show genetically that plexin-1 is part of the same functional pathway as semaphorin-1 and -2 for C. elegans male ray cell positioning.
      Title: Conversion of cell movement responses to Semaphorin-1 and Plexin-1 from attraction to repulsion by lowered levels of specific RAC GTPases in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode male tail mating organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sema domain-containing protein;Semaphorin-1A
    NP_001370129.1
    • Confirmed by transcript evidence
    NP_001391076.1
    • Confirmed by transcript evidence
    NP_493582.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14807462..14815729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001404220.1 → NP_001391076.1  Sema domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SVH9

    2. NM_001383767.1 → NP_001370129.1  Sema domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Q16
      Conserved Domains (1) summary
      cl15693
      Location:49 → 247
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    3. NM_061181.8 → NP_493582.3  Semaphorin-1A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493582.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17330, Q9XWF8
      Conserved Domains (2) summary
      cd11237
      Location:49 → 497
      Sema_1A; The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A)
      smart00423
      Location:496 → 547
      PSI; domain found in Plexins, Semaphorins and Integrins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17330.2

    Gene LinkOut

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