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    F07F6.4 Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 173927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F07F6.4
    Official Full Name
    Uncharacterized protein
    Primary source
    WormBase:WBGene00017217
    Locus tag
    CELE_F07F6.4
    See related
    AllianceGenome:WB:WBGene00017217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in Golgi membrane. Is expressed in intestine; nervous system; and rectal gland cell. Orthologous to several human genes including ARFGAP2 (ADP ribosylation factor GTPase activating protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F07F6.4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (5427449..5429572, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Embryonic developmental protein tofu-6 Neighboring gene Apolipoprotein L, 1 Neighboring gene Apolipoprotein L3-like Neighboring gene Uncharacterized protein Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene Protein dct-5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPI coating of Golgi vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uncharacterized protein
    NP_495029.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5427449..5429572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062628.7 → NP_495029.2  Uncharacterized protein CELE_F07F6.4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495029.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09531
      Conserved Domains (1) summary
      smart00105
      Location:16 → 129
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09531.2

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