pab-2 Polyadenylate-binding protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pab-2
Official Full Name: Polyadenylate-binding protein
Primary source: WormBase:WBGene00003903
Locus tag: CELE_F18H3.3
See related: AllianceGenome:WB:WBGene00003903
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Located in cytoplasm. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1) and PABPC3 (poly(A) binding protein cytoplasmic 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pab-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (13522262..13525823, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was found that C. elegans PAB1 and PAB2 are required for miRNA-mediated silencing in embryonic and larval developmental stages, where they act through a multi-faceted mechanism.
Title: Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F18H3.3 (e-PCR)
- UniSTS:317475

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Polyadenylate-binding protein

NP_001379081.1

Confirmed by transcript evidence

NP_001379082.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13522262..13525823 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392873.1 → NP_001379081.1 Polyadenylate-binding protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q19579

Conserved Domains (1) summary

TIGR01628
Location:57 → 675

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
NM_001392874.1 → NP_001379082.1 Polyadenylate-binding protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q19581

Conserved Domains (1) summary

TIGR01628
Location:1 → 558

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family