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    gly-20 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [ Caenorhabditis elegans ]

    Gene ID: 179562, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gly-20
    Official Full Name
    Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Primary source
    WormBase:WBGene00001645
    Locus tag
    CELE_C03E10.4
    See related
    AllianceGenome:WB:WBGene00001645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Involved in protein N-linked glycosylation. Predicted to be located in Golgi stack and membrane. Predicted to be active in Golgi membrane. Used to study carbohydrate metabolic disorder. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gly-20 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (11282572..11286039)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G protein-coupled receptor Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SweetBac: a new approach for the production of mammalianised glycoproteins in insect cells. Palmberger D, et al. PLoS One, 2012. PMID 22485160, Free PMC Article
    2. Mitochondrial complex I function affects halothane sensitivity in Caenorhabditis elegans. Kayser EB, et al. Anesthesiology, 2004 Aug. PMID 15277919
    3. Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1. Kayser EB, et al. J Biol Chem, 2004 Dec 24. PMID 15269213
    4. Alternative polyadenylation results in a truncated daf-4 BMP receptor that antagonizes DAF-7-mediated development in Caenorhabditis elegans. Gunther CV, et al. J Biol Chem, 2004 Sep 17. PMID 15254038
    5. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I and UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II in Caenorhabditis elegans. Chen S, et al. Biochim Biophys Acta, 2002 Dec 19. PMID 12417409

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    NP_505864.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11282572..11286039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073463.9 → NP_505864.1  Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17560, Q9NGK7
      Conserved Domains (1) summary
      pfam05060
      Location:101 → 447
      MGAT2; N-acetylglucosaminyltransferase II (MGAT2)
    Nucleotide Protein
    Heading Accession and Version

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