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    skp-1 mammalian SKIP (Ski interacting protein) homolog [ Caenorhabditis elegans ]

    Gene ID: 179598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    skp-1
    Official Full Name
    mammalian SKIP (Ski interacting protein) homolog
    Primary source
    WormBase:WBGene00004806
    Locus tag
    CELE_T27F2.1
    See related
    AllianceGenome:WB:WBGene00004806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including egg-laying behavior; uterus development; and vulval development. Predicted to be part of spliceosomal complex. Is expressed in egg-laying apparatus; hypodermis; pharynx; rectal muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human SNW1 (SNW domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See skp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (11645481..11650090)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chromosomal passenger complex protein bir-1 Neighboring gene Transcription factor zip-10 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SKIP is an indispensable factor for Caenorhabditis elegans development. Kostrouchova M, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12084813, Free PMC Article
    2. BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development. Kostrouchova M, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12682297, Free PMC Article
    3. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Zhou S, et al. Mol Cell Biol, 2000 Apr. PMID 10713164, Free PMC Article
    4. Functional recovery of the germ line following splicing collapse. Cao W, et al. Cell Death Differ, 2022 Apr. PMID 34663906, Free PMC Article
    5. BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans. Libý P, et al. Folia Biol (Praha), 2006. PMID 17116281

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Skp1 proteins are structural components of the synaptonemal complex in C. elegans.
      Title: Skp1 proteins are structural components of the synaptonemal complex in C. elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in uterus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mammalian SKIP (Ski interacting protein) homolog
    NP_505950.1
    • Product from WormBase gene class skp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11645481..11650090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073549.10 → NP_505950.1  mammalian SKIP (Ski interacting protein) homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22836
      Conserved Domains (1) summary
      pfam02731
      Location:183 → 323
      SKIP_SNW; SKIP/SNW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22836.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.