ced-10 Ras-related protein ced-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ced-10
Official Full Name: Ras-related protein ced-10
Primary source: WormBase:WBGene00000424
Locus tag: CELE_C09G12.8
See related: AllianceGenome:WB:WBGene00000424
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTP binding activity and GTPase activity. Involved in several processes, including axon development; cytoskeleton organization; and embryonic morphogenesis. Located in cytoplasmic side of plasma membrane; cytoplasmic vesicle; and neuronal cell body. Is expressed in several structures, including CAN; GABAergic neurons; distal tip cell; intestine; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); combined immunodeficiency (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to several human genes including RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ced-10 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (3506328..3509527, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1.
Title: Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1.
RAC1/ced-10 participates in Parkinson's disease associated pathogenesis
Title: The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity.
A single glycine residue in a conserved domain of the C. elegans CED-10 is crucial for controlling neurite outgrowth in a partially non-redundant manner. When CED-10 function is diminished, the adaptor protein NAB-1 and its interacting partner SYD-1 can act as inhibitors of axon outgrowth.
Title: Distinct CED-10/Rac1 domains confer context-specific functions in development.
CHDP-1 associates through its calponin homology domain with the small GTPase Rac1/CED-10, which is a key regulator of the actin cytoskeleton
Title: The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions.
UNC-73, the C. elegans ortholog of Trio, is a guanine nucleotide exchange factor (GEF) upstream of both CED-10 and MIG-2 that is suppressed by CMRL1
Title: Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans.
C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum.
Title: C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum.
RIN-1 acts with CED-10 in the regulation of filopodia formation.
Title: The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans.
we show that CED-10 binds to the RAB-5 GTPase activating protein TBC-2, that CED-10 contributes to recruitment of TBC-2 to endosomes, and that recycling cargo is trapped in recycling endosomes in ced-12, ced-10, and tbc-2 mutants
Title: CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.
Results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton.
Title: The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
mutations in GAP domain of CYK-4 lead to cytokinesis defects mimicking centralspindlin loss of function; defects could be rescued by depletion Rac; inactivation of Rac by centralspindlin functions in parallel with RhoA activation in cytokinesis
Title: Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09G12.8a (e-PCR)
- UniSTS:319997

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemorepulsion of axon	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in left/right axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in left/right axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of microtubule polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in organelle organization	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of distal tip cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dorsal/ventral axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ras-related protein ced-10

NP_500362.3

Confirmed by transcript evidence

NP_500363.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3506328..3509527 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067962.7 → NP_500363.1 Ras-related protein ced-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500363.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44463, O44464, Q03206

Conserved Domains (1) summary

cd01871
Location:3 → 176

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3
NM_067961.6 → NP_500362.3 Ras-related protein ced-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500362.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03206

Conserved Domains (2) summary

smart00174
Location:6 → 117

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cl21455
Location:3 → 114

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases