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    enu-3.1 ENhancer of Uncoordination [ Caenorhabditis elegans ]

    Gene ID: 176463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    enu-3.1
    Official Full Name
    ENhancer of Uncoordination
    Primary source
    WormBase:WBGene00010362
    Locus tag
    CELE_H04D03.1
    See related
    AllianceGenome:WB:WBGene00010362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in axon extension involved in axon guidance. Located in neuronal cell body. Is expressed in head; nervous system; and seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See enu-3.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (10436276..10438142)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp3 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog Neighboring gene ncRNA Neighboring gene MLX-interacting protein;Ovule protein Neighboring gene DUF1330 domain-containing protein;PHD-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ENU-3 family proteins function in a pathway parallel to the UNC-6/Netrin pathway for motor neuron axon outgrowth, most likely in the Wnt pathway.
      Title: The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans.
    2. identified a novel mutant, enu-3 (enhancer of Unc), that enhances the motor neuron axon outgrowth defects observed in strains that lack either the UNC-5 receptor or its ligand UNC-6/Netrin
      Title: ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans.
    3. ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.
      Title: ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon extension involved in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ENhancer of Uncoordination
    NP_499302.1
    • Product from WormBase gene class enu;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10436276..10438142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066901.6 → NP_499302.1  ENhancer of Uncoordination [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45607
      Conserved Domains (1) summary
      pfam04795
      Location:149 → 202
      PAPA-1; PAPA-1-like conserved region
    Nucleotide Protein
    Heading Accession and Version

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