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    MPZ myelin protein zero [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719969, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MPZprovided by VGNC
    Official Full Name
    myelin protein zeroprovided by VGNC
    Primary source
    VGNC:VGNC:74923
    See related
    Ensembl:ENSMMUG00000001216
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Summary
    This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in the orthologous gene in human are associated with myelinating neuropathies. A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Mar 2016]
    Orthologs
    human mouse all
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    Genomic context

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    See MPZ in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (89637308..89642506)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (136035692..136040883, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106993201 Neighboring gene cilia and flagella associated protein 126 Neighboring gene succinate dehydrogenase complex subunit C Neighboring gene Purkinje cell protein 4 like 1 Neighboring gene nuclear receptor subfamily 1 group I member 3 Neighboring gene translocase of outer mitochondrial membrane 40 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetically Conserved Sequences Around Myelin P0 Stop Codon are Essential for Translational Readthrough to Produce L-MPZ. Yamaguchi Y, et al. Neurochem Res, 2018 Jan. PMID 29081003
    2. L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. Yamaguchi Y, et al. J Biol Chem, 2012 May 18. PMID 22457349, Free PMC Article
    3. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myelin protein P0

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321055.2 → NP_001307984.1  myelin protein P0 isoform MPZ precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (MPZ).
      Source sequence(s)
      QNVO02000011
      UniProtKB/TrEMBL
      A0A5F8A6B8, G7MEA0
      Related
      ENSMMUP00000072490.1, ENSMMUT00000084307.1
      Conserved Domains (3) summary
      cd05879
      Location:31 → 146
      Ig_P0; Immunoglobulin (Ig)-like domain of Protein zero (P0)
      smart00410
      Location:36 → 146
      IG_like; Immunoglobulin like
      pfam10570
      Location:184 → 248
      Myelin-PO_C; Myelin-PO cytoplasmic C-term p65 binding region

    2. NM_001321056.2 → NP_001307985.1  myelin protein P0 isoform L-MPZ precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (MPZ, also known as P0) results from translation termination at the upstream UAG stop codon, while the longer isoform (L-MPZ) results from UAG stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (L-MPZ). As the UAG stop codon has been reported to specify several alternative amino acids (glutamine, tyrosine and leucine), its location in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      QNVO02000011
      Conserved Domains (3) summary
      cd05879
      Location:31 → 146
      Ig_P0; Immunoglobulin (Ig)-like domain of Protein zero (P0)
      smart00410
      Location:36 → 146
      IG_like; Immunoglobulin like
      pfam10570
      Location:184 → 248
      Myelin-PO_C; Myelin-PO cytoplasmic C-term p65 binding region

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      89637308..89642506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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