F7 coagulation factor VII [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: F7provided by VGNC
Official Full Name: coagulation factor VIIprovided by VGNC
Primary source: VGNC:VGNC:72466
See related: Ensembl:ENSMMUG00000001036
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	17	NC_041770.1 (94350062..94362501)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	17	NC_027909.1 (94584331..94596886)

Chromosome 17 - NC_041770.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study reports the full-length cDNA sequences of rhesus monkey FVII; deduced protein sequence of FVII indicates the functional domains; comparison of three-dimensional protein structure with human shows high conservation between them
Title: Full-length cDNA cloning and protein three-dimensional structure modeling of factor VII of rhesus monkey, Macaca mulatta.

Submit: New GeneRIF Correction

General gene information

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Markers

ECD07207 (e-PCR)
- UniSTS:288264

G15852 (e-PCR)
- UniSTS:33878

ECD13274 (e-PCR)
- UniSTS:294304

REN18404 (e-PCR)
- UniSTS:343204

REN18406 (e-PCR)
- UniSTS:343206

REN18407 (e-PCR)
- UniSTS:343207

REN18413 (e-PCR)
- UniSTS:343213

ECD03249 (e-PCR)
- UniSTS:284334

REN18416 (e-PCR)
- UniSTS:343216

REN18423 (e-PCR)
- UniSTS:343223

REN18425 (e-PCR)
- UniSTS:343225

REN18434 (e-PCR)
- UniSTS:343234

REN18436 (e-PCR)
- UniSTS:343236

REN18437 (e-PCR)
- UniSTS:343237

REN18441 (e-PCR)
- UniSTS:343241

REN18442 (e-PCR)
- UniSTS:343242

REN18448 (e-PCR)
- UniSTS:343248

REN18449 (e-PCR)
- UniSTS:343249

ECD13839 (e-PCR)
- UniSTS:294865

REN18453 (e-PCR)
- UniSTS:343253

REN18454 (e-PCR)
- UniSTS:343254

ha2531 (e-PCR)
- UniSTS:515558

stSG621980 (e-PCR)
- UniSTS:454638

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: coagulation factor VII

NP_001073605.1

EC 3.4.21.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080136.1 → NP_001073605.1 coagulation factor VII precursor

See identical proteins and their annotated locations for NP_001073605.1

Status: PROVISIONAL

Source sequence(s)

EF061407

UniProtKB/TrEMBL

A0A0B4J1C9, A0N0C5

Related

ENSMMUP00000001388.4, ENSMMUT00000001477.4

Conserved Domains (5) summary

smart00020
Location:218 → 452

Tryp_SPc; Trypsin-like serine protease

smart00069
Location:48 → 110

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:112 → 148

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:219 → 455

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam14670
Location:157 → 193

FXa_inhibition; Coagulation Factor Xa inhibitory site