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    FAS Fas cell surface death receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574332, updated on 14-Nov-2024

    Summary

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    Official Symbol
    FASprovided by VGNC
    Official Full Name
    Fas cell surface death receptorprovided by VGNC
    Primary source
    VGNC:VGNC:72479
    See related
    Ensembl:ENSMMUG00000009339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CD95
    Orthologs
    human mouse all
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    Genomic context

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    See FAS in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (89258065..89283471)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (84174170..84199616)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene STAM binding protein like 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene small nucleolar RNA U13 Neighboring gene zinc finger RNA-binding protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fas and FasL expression in the spinal cord following cord hemisection in the monkey. Jia L, et al. Neurochem Res, 2011 Mar. PMID 21181266
    2. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Villinger F, et al. Immunogenetics, 2001 May-Jun. PMID 11491535
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tumor necrosis factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in motor neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in necroptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 6
    Names
    FASLG receptor
    Fas (TNF receptor superfamily, member 6)
    Fas receptor CD95
    apo-1 antigen
    apoptosis-mediating surface antigen FAS

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032933.2 → NP_001028105.1  tumor necrosis factor receptor superfamily member 6 precursor

      See identical proteins and their annotated locations for NP_001028105.1

      Status: PROVISIONAL

      Source sequence(s)
      AF344833
      UniProtKB/Swiss-Prot
      Q9BDP2
      UniProtKB/TrEMBL
      F6V1W6, H9Z8J8
      Related
      ENSMMUP00000014651.3, ENSMMUT00000015642.4
      Conserved Domains (2) summary
      cd08316
      Location:224 → 317
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:39 → 167
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      89258065..89283471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015147623.2 → XP_015003109.2  tumor necrosis factor receptor superfamily member 6 isoform X3

      UniProtKB/TrEMBL
      F6V1W6, H9Z8J8
      Conserved Domains (2) summary
      cd08316
      Location:201 → 294
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:39 → 167
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    2. XM_015147622.2 → XP_015003108.2  tumor necrosis factor receptor superfamily member 6 isoform X2

      UniProtKB/TrEMBL
      F6V1W6, H9Z8J8
      Conserved Domains (2) summary
      cd08316
      Location:221 → 314
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:59 → 187
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

    3. XM_015147621.2 → XP_015003107.2  tumor necrosis factor receptor superfamily member 6 isoform X1

      UniProtKB/TrEMBL
      A0A1D5R6H4, F6V1W6, H9Z8J8
      Related
      ENSMMUP00000055912.2, ENSMMUT00000055497.2
      Conserved Domains (2) summary
      cd08316
      Location:244 → 337
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd10579
      Location:59 → 187
      TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BDP2.1 GenPept UniProtKB/Swiss-Prot:Q9BDP2

    Gene LinkOut

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