TLR7 toll like receptor 7 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: TLR7provided by VGNC
Official Full Name: toll like receptor 7provided by VGNC
Primary source: VGNC:VGNC:78390
See related: Ensembl:ENSMMUG00000014254
Gene type: protein coding
RefSeq status: INFERRED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: X

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	X	NC_041774.1 (12511357..12534481)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	X	NC_027913.1 (12080063..12083210)

Chromosome X - NC_041774.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In contrast to humans, plasmacytoid dendritic cells in rhesus macaques express the interleukin (IL)-12p40 subunit in response to TLR-7/8 as well as TLR-9 agonist stimulation.
Title: Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.
analyzed polymorphisms in TLR7 gene in the rhesus macaque model of AIDS; in c.13A carriers, neither set-point viral load nor survival time were related to c.-17C>T genotype; in c.13G carriers c.-17C allele wasassociated with prolonged survival
Title: Association of TLR7 variants with AIDS-like disease and AIDS vaccine efficacy in rhesus macaques.
Data suggest that the response pattern of human and rhesus B cells and pDCs to TLR7/8 and TLR9 is similar, although some differences in the cell surface phenotype of the differentiating cells exist.
Title: Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

TLR7 (e-PCR)
- UniSTS:506514

PMC128073P8 (e-PCR)
- UniSTS:270570

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables pattern recognition receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor 7 signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: toll-like receptor 7

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130426.2 → NP_001123898.1 toll-like receptor 7

See identical proteins and their annotated locations for NP_001123898.1

Status: INFERRED

Source sequence(s)

AB445665, JU472848, JU487786, QNVO02003165

UniProtKB/TrEMBL

B3Y653, G8E2R2

Related

ENSMMUP00000018719.2, ENSMMUT00000020000.4

Conserved Domains (6) summary

TIGR00864
Location:753 → 837

PCC; polycystin cation channel protein

smart00255
Location:890 → 993

TIR; Toll - interleukin 1 - resistance

COG4886
Location:488 → 775

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:496 → 518

LRR_RI; leucine-rich repeat [structural motif]

cl26018
Location:23 → 259

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:191 → 712

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional