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    RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694725, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RAF1provided by VGNC
    Official Full Name
    Raf-1 proto-oncogene, serine/threonine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:76649
    See related
    Ensembl:ENSMMUG00000007450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RAF1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (143956554..144039447, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (53732851..53818349)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin ring finger protein 2 Neighboring gene transmembrane protein 40 Neighboring gene keratin, type I cytoskeletal 18 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RAF proto-oncogene serine/threonine-protein kinase
    Names
    v-raf-1 murine leukemia viral oncogene homolog 1
    NP_001253231.1
    XP_014985690.1
    XP_014985692.1
    XP_028698921.1
    XP_028698922.1
    XP_028698923.1
    XP_028698924.1
    XP_028698925.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266302.1 → NP_001253231.1  RAF proto-oncogene serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_001253231.1

      Status: PROVISIONAL

      Source sequence(s)
      JV047817
      UniProtKB/TrEMBL
      F6SWC0, G7MKP4
      Related
      ENSMMUP00000009777.2, ENSMMUT00000010416.4
      Conserved Domains (3) summary
      cd14149
      Location:336 → 618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      143956554..144039447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028843088.1 → XP_028698921.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A1D5R9U8, G7MKP4
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:139 → 184
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    2. XM_028843092.1 → XP_028698925.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      UniProtKB/TrEMBL
      G7MKP4
      Conserved Domains (2) summary
      cd14149
      Location:275 → 557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58 → 103
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. XM_015130206.2 → XP_014985692.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      UniProtKB/TrEMBL
      G7MKP4
      Conserved Domains (2) summary
      cd14149
      Location:255 → 537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58 → 106
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. XM_015130204.2 → XP_014985690.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      F6SWC0, G7MKP4
      Related
      ENSMMUP00000067200.1, ENSMMUT00000088856.1
      Conserved Domains (3) summary
      cd14149
      Location:336 → 618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136 → 187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    5. XM_028843090.1 → XP_028698923.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A1D5R9U8, G7MKP4
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:139 → 184
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    6. XM_028843091.1 → XP_028698924.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A1D5R9U8, G7MKP4
      Related
      ENSMMUP00000057089.1, ENSMMUT00000072482.2
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:139 → 184
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF

    7. XM_028843089.1 → XP_028698922.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A1D5R9U8, G7MKP4
      Conserved Domains (3) summary
      cd14149
      Location:356 → 638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:139 → 184
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cd17135
      Location:55 → 131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    Nucleotide Protein
    Heading Accession and Version

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