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    ITGB4 integrin subunit beta 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 703770, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ITGB4provided by VGNC
    Official Full Name
    integrin subunit beta 4provided by VGNC
    Primary source
    VGNC:VGNC:99159
    See related
    Ensembl:ENSMMUG00000021763
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ITGB4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (72087850..72126393)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (69430417..69469809)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene RecQ like helicase 5 Neighboring gene endoregulin Neighboring gene SAP30 binding protein Neighboring gene galactokinase 1 Neighboring gene H3.3 histone B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hemidesmosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin beta-4
    Names
    integrin, beta 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      72087850..72126393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028836798.1 → XP_028692631.1  integrin beta-4 isoform X2

      UniProtKB/TrEMBL
      A0A1D5Q7P8
      Conserved Domains (6) summary
      smart00187
      Location:37 → 454
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      cd00063
      Location:1512 → 1593
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:544 → 574
      EGF_2; EGF-like domain
      pfam03160
      Location:991 → 1085
      Calx-beta; Calx-beta domain
      pfam00041
      Location:1626 → 1711
      fn3; Fibronectin type III domain
      pfam07965
      Location:627 → 709
      Integrin_B_tail; Integrin beta tail domain

    2. XM_015120393.2 → XP_014975879.1  integrin beta-4 isoform X4

      UniProtKB/TrEMBL
      F7DF99, G7NGQ4, I2CYL9
      Related
      ENSMMUP00000028661.4, ENSMMUT00000030624.4
      Conserved Domains (6) summary
      cd00063
      Location:1221 → 1314
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1530 → 1612
      fn3; Fibronectin type III domain
      pfam00362
      Location:37 → 454
      Integrin_beta; Integrin, beta chain
      pfam03160
      Location:991 → 1085
      Calx-beta; Calx-beta domain
      pfam07965
      Location:627 → 709
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:544 → 574
      EGF_2; EGF-like domain

    3. XM_028836797.1 → XP_028692630.1  integrin beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q7P8, I2CYM0
      Related
      ENSMMUP00000055009.1, ENSMMUT00000062841.2
      Conserved Domains (6) summary
      smart00187
      Location:37 → 454
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      cd00063
      Location:1512 → 1593
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:544 → 574
      EGF_2; EGF-like domain
      pfam03160
      Location:991 → 1085
      Calx-beta; Calx-beta domain
      pfam00041
      Location:1626 → 1711
      fn3; Fibronectin type III domain
      pfam07965
      Location:627 → 709
      Integrin_B_tail; Integrin beta tail domain

    4. XM_028836799.1 → XP_028692632.1  integrin beta-4 isoform X3

      UniProtKB/TrEMBL
      F6Y9Y1, G7NGQ4
      Related
      ENSMMUP00000029678.4, ENSMMUT00000031722.4
      Conserved Domains (6) summary
      smart00187
      Location:37 → 454
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      cd00063
      Location:1459 → 1540
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07974
      Location:544 → 574
      EGF_2; EGF-like domain
      pfam03160
      Location:991 → 1085
      Calx-beta; Calx-beta domain
      pfam00041
      Location:1573 → 1658
      fn3; Fibronectin type III domain
      pfam07965
      Location:627 → 709
      Integrin_B_tail; Integrin beta tail domain

    RNA

    1. XR_003723882.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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