IL2 interleukin 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: IL2provided by VGNC
Official Full Name: interleukin 2provided by VGNC
Primary source: VGNC:VGNC:100237
See related: Ensembl:ENSMMUG00000021093
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: IL-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	5	NC_041758.1 (120302362..120307091, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	5	NC_027897.1 (121451957..121456686, complement)

Chromosome 5 - NC_041758.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The reduction of CD58 expression in T cells was correlated with the reduced expression of T-cell-mediated IL-2 and TNFalpha production. Together, these results indicate that reduction in the CD2/CD58 interaction pathway in mucosal lymphocytes might play a crucial role in mucosal T-cell dysfunction during acute SIV/HIV infection.
Title: Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.

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General gene information

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Markers

IL2_s19 (e-PCR)
- UniSTS:511815

IL2 (e-PCR)
- UniSTS:266092

SHGC-59515 (e-PCR)
- UniSTS:13438

IL2 (e-PCR)
- UniSTS:479872

GDB:625818 (e-PCR)
- UniSTS:158367

GDB:625821 (e-PCR)
- UniSTS:158368

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-2 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-2

Names: T-cell growth factor; TCGF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.