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    CD8A CD8 subunit alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698329, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CD8Aprovided by VGNC
    Official Full Name
    CD8 subunit alphaprovided by VGNC
    Primary source
    VGNC:VGNC:70786
    See related
    Ensembl:ENSMMUG00000003524
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See CD8A in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (19092978..19100027)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (89336430..89343471, complement)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106993044 Neighboring gene histone-lysine N-methyltransferase SUV39H2 pseudogene Neighboring gene CD8 subunit beta Neighboring gene required for meiotic nuclear division 5 homolog A Neighboring gene uncharacterized LOC114671854

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities. Vargas-Inchaustegui DA, et al. Immunology, 2011 Nov. PMID 21978002, Free PMC Article
    2. Rhesus macaque: a tight homodimeric CD8alphaalpha. Zong L, et al. Proteins, 2009 Apr. PMID 19137599
    3. TLR3-responsive, XCR1+, CD141(BDCA-3)+/CD8α+-equivalent dendritic cells uncovered in healthy and simian immunodeficiency virus-infected rhesus macaques. Dutertre CA, et al. J Immunol, 2014 May 15. PMID 24740505
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TLR3-responsive, XCR1+, CD141(BDCA-3)+/CD8alpha+-equivalent dendritic cells uncovered in healthy and simian immunodeficiency virus-infected rhesus macaques.
      Title: TLR3-responsive, XCR1+, CD141(BDCA-3)+/CD8α+-equivalent dendritic cells uncovered in healthy and simian immunodeficiency virus-infected rhesus macaques.
    2. Data show that about 35% of macaque CD8alpha(-) cells represent a novel, functional population of circulatory NK cells that possesses cytotoxic potential and is capable of mediating anti-viral immune responses.
      Title: A CD8α(-) subpopulation of macaque circulatory natural killer cells can mediate both antibody-dependent and antibody-independent cytotoxic activities.
    3. Presented is the crystal structure of rhesus macaque CD8 (rCD8) homodimer and compared with that of human/mouse CD8 homodimer; two Thr43 residues in C-C loop of rCD8 show an extra hydrogen bond indicating a tighter homodimeric interaction.
      Title: Rhesus macaque: a tight homodimeric CD8alphaalpha.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    T-cell surface glycoprotein CD8 alpha chain
    Names
    CD8a molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      19092978..19100027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001092778.4 → XP_001092778.2  T-cell surface glycoprotein CD8 alpha chain

      UniProtKB/TrEMBL
      F7DXL7
      Conserved Domains (1) summary
      cd05720
      Location:72 → 174
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain

    2. XM_028832320.1 → XP_028688153.1  T-cell surface glycoprotein CD8 alpha chain

      UniProtKB/TrEMBL
      F7DXL7
      Related
      ENSMMUP00000004696.2, ENSMMUT00000004987.3
      Conserved Domains (1) summary
      cd05720
      Location:72 → 174
      Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain
    Nucleotide Protein
    Heading Accession and Version

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