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    BST2 bone marrow stromal cell antigen 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 719092, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BST2provided by VGNC
    Official Full Name
    bone marrow stromal cell antigen 2provided by VGNC
    Primary source
    VGNC:VGNC:70286
    See related
    Ensembl:ENSMMUG00000005829
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    BST-2; CD317; BST2.1; BST2.3; BST2.4; BST2.5; BST2.6; BST2.7; BST2.9; BST2.10; BST2.11; BST2.12; BST2.13; BST2.14; BST2.15
    Orthologs
    human mouse all
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    Genomic context

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    See BST2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 19 NC_041772.1 (16904963..16907635, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 19 NC_027911.1 (17343262..17345922, complement)

    Chromosome 19 - NC_041772.1Genomic Context describing neighboring genes Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene uncharacterized LOC114674033 Neighboring gene multivesicular body subunit 12A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms in Rhesus Macaque Tetherin Are Associated with Differences in Acute Viremia in Simian Immunodeficiency Virus Δnef-Infected Animals. Janaka SK, et al. J Virol, 2018 Nov 15. PMID 30135127, Free PMC Article
    2. Increased BST2 expression during simian immunodeficiency virus infection is not a determinant of disease progression in rhesus monkeys. Mussil B, et al. Retrovirology, 2015 Nov 10. PMID 26554913, Free PMC Article
    3. Tetherin upregulation in simian immunodeficiency virus-infected macaques. Rahmberg AR, et al. J Virol, 2013 Dec. PMID 24109219, Free PMC Article
    4. Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIV. Serra-Moreno R, et al. Cell Host Microbe, 2011 Jan 20. PMID 21238946, Free PMC Article
    5. Functional antagonism of rhesus macaque and chimpanzee BST-2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions. Yoshida T, et al. J Virol, 2013 Dec. PMID 24109238, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the detected relationship between BST2 expression and viral load as well as with MX1 indicate a common regulation by the interferon response and suggest rather limited influence of BST2 in vivo on the simian immunodeficiency virus infection outcome
      Title: Increased BST2 expression during simian immunodeficiency virus infection is not a determinant of disease progression in rhesus monkeys.
    2. Data suggest that rhesus macaque tetherin and Simian immunodeficiency virus Nef undergo physical interaction leading to removal of tetherin from plasma membrane by clathrin-mediated endocytosis.
      Title: Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.
    3. A 5-amino-acid sequence in the rhesus BST-2 cytoplasmic domain accounts for the interaction with Vpu and for rhesus BST-2 antagonism by HIV-1 Vpu.
      Title: Functional antagonism of rhesus macaque and chimpanzee BST-2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions.
    4. Simian immunodeficiency virus infection results in rapid upregulation of BST-2 on peripheral blood lymphocytes.
      Title: Tetherin upregulation in simian immunodeficiency virus-infected macaques.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bone marrow stromal antigen 2
    Names
    tetherin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161666.1 → NP_001155138.1  bone marrow stromal antigen 2

      See identical proteins and their annotated locations for NP_001155138.1

      Status: PROVISIONAL

      Source sequence(s)
      FJ868941
      UniProtKB/TrEMBL
      C4P4A2, G0WVJ8, G7NMR6
      Related
      ENSMMUP00000007685.3, ENSMMUT00000008172.4
      Conserved Domains (1) summary
      pfam16716
      Location:52 → 136
      BST2; Bone marrow stromal antigen 2

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041772.1 Reference Mmul_10 Primary Assembly

      Range
      16904963..16907635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015123240.2 → XP_014978726.2  bone marrow stromal antigen 2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q5T5, A0A346NV76, C3W5K9
      Related
      ENSMMUP00000043401.2, ENSMMUT00000077200.2
      Conserved Domains (1) summary
      pfam16716
      Location:52 → 136
      BST2; Bone marrow stromal antigen 2
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.