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    SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717169, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SRGAP1provided by VGNC
    Official Full Name
    SLIT-ROBO Rho GTPase activating protein 1provided by VGNC
    Primary source
    VGNC:VGNC:77939
    Locus tag
    EGK_03876
    See related
    Ensembl:ENSMMUG00000001952
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SRGAP1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (63412313..63719668)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (62612678..62919649)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene ribitol xylosyltransferase 1 Neighboring gene polyadenylate-binding protein 1 pseudogene Neighboring gene 60S ribosomal protein L36a-like Neighboring gene uncharacterized LOC107000912 Neighboring gene U6 spliceosomal RNA Neighboring gene KICSTOR subunit 2 Neighboring gene chromosome 11 C12orf56 homolog Neighboring gene 40S ribosomal protein S18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SLIT-ROBO Rho GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      63412313..63719668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015152203.2 → XP_015007689.1  SLIT-ROBO Rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A663DCF4, A0A8J8YND0, F6VHB1, F6VHC8, G7N7I9
      Related
      ENSMMUP00000002610.4, ENSMMUT00000002765.4
      Conserved Domains (3) summary
      cd07683
      Location:26 → 278
      F-BAR_srGAP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 1
      cd11955
      Location:747 → 799
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:502 → 689
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

    2. XM_015152204.2 → XP_015007690.1  SLIT-ROBO Rho GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5R278, F6VHC8
      Related
      ENSMMUP00000054412.2, ENSMMUT00000059814.2
      Conserved Domains (4) summary
      cd07683
      Location:26 → 278
      F-BAR_srGAP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 1
      cd11955
      Location:724 → 776
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:482 → 666
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
      pfam03867
      Location:960 → 1059
      FTZ; Fushi tarazu (FTZ), N-terminal region
    Nucleotide Protein
    Heading Accession and Version

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