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    TGFBR2 transforming growth factor beta receptor 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 703088, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TGFBR2provided by VGNC
    Official Full Name
    transforming growth factor beta receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:78338
    See related
    Ensembl:ENSMMUG00000010031
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TGFBR2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (17035106..17123221, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (190441251..190529470, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene glutamate decarboxylase like 1 Neighboring gene uncharacterized LOC114676225 Neighboring gene uncharacterized LOC106997160 Neighboring gene uncharacterized LOC106997161

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection. George J, et al. J Virol, 2015 Mar. PMID 25540365, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of microRNA miR-155 was significantly upregulated in the oropharyngeal mucosa during chronic SIV infection and was coincident with downregulation of TGFbeta receptor 2 (TGFbeta-R2) and SMAD5.
      Title: Suppression of transforming growth factor β receptor 2 and Smad5 is associated with high levels of microRNA miR-155 in the oral mucosa during chronic simian immunodeficiency virus infection.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables activin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables activin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transforming growth factor beta receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables type I transforming growth factor beta receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TGF-beta receptor type-2
    Names
    transforming growth factor, beta receptor II (70/80kDa)
    NP_001248080.1
    XP_014987809.1
    XP_014987810.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261151.1 → NP_001248080.1  TGF-beta receptor type-2 precursor

      See identical proteins and their annotated locations for NP_001248080.1

      Status: PROVISIONAL

      Source sequence(s)
      JV043253
      UniProtKB/TrEMBL
      A0A1D5RJL2, G8F1I4, H9YUL0
      Related
      ENSMMUP00000060506.2, ENSMMUT00000063908.2
      Conserved Domains (3) summary
      smart00221
      Location:244 → 544
      STYKc; Protein kinase; unclassified specificity
      cd14055
      Location:248 → 542
      STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
      pfam08917
      Location:49 → 152
      ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      17035106..17123221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015132323.2 → XP_014987809.1  TGF-beta receptor type-2 isoform X1

      UniProtKB/TrEMBL
      F6Q1B1, G8F1I4
      Related
      ENSMMUP00000013111.3, ENSMMUT00000014002.4
      Conserved Domains (3) summary
      smart00221
      Location:269 → 569
      STYKc; Protein kinase; unclassified specificity
      cd14055
      Location:273 → 567
      STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
      pfam08917
      Location:74 → 177
      ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain

    2. XM_015132324.2 → XP_014987810.1  TGF-beta receptor type-2 isoform X2

      UniProtKB/TrEMBL
      G8F1I4
      Conserved Domains (3) summary
      smart00221
      Location:221 → 521
      STYKc; Protein kinase; unclassified specificity
      cd14055
      Location:225 → 519
      STKc_TGFbR2_like; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor
      pfam08917
      Location:26 → 129
      ecTbetaR2; Transforming growth factor beta receptor 2 ectodomain
    Nucleotide Protein
    Heading Accession and Version

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