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    GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574302, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GABRA1provided by VGNC
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit alpha1provided by VGNC
    Primary source
    VGNC:VGNC:72846
    Locus tag
    EGK_17100
    See related
    Ensembl:ENSMMUG00000007296
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GABRA1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (159259664..159315700)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (160093850..160150300)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106999019 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha6 Neighboring gene uncharacterized LOC106999023 Neighboring gene uncharacterized LOC106999024 Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence. Hillmer AT, et al. Alcohol Clin Exp Res, 2016 Apr. PMID 26971694, Free PMC Article
    2. Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys. Makaron L, et al. Pharmacol Biochem Behav, 2013 Mar. PMID 23290931, Free PMC Article
    3. Protracted developmental trajectories of GABAA receptor alpha1 and alpha2 subunit expression in primate prefrontal cortex. Hashimoto T, et al. Biol Psychiatry, 2009 Jun 15. PMID 19249749, Free PMC Article
    4. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    5. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neither nicotine nor nicotine abstinence interferes with GABAA receptor neuroadaptations during alcohol withdrawal.
      Title: Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence.
    2. evaluated the role of alpha1 and alpha5 subunit-containing GABAA receptors (alpha1GABAA and alpha5GABAA receptors, respectively) in the ability of benzodiazepine-type drugs to alter performance in the cognitive domain of executive function
      Title: Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.
    3. the developmental shift in GABA(A) receptor alpha subunit expression continues through adolescence in primate dorsolateral prefrontal cortex
      Title: Protracted developmental trajectories of GABAA receptor alpha1 and alpha2 subunit expression in primate prefrontal cortex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GABA-gated chloride ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables benzodiazepine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-1
    Names
    gamma-aminobutyric acid (GABA) A receptor, alpha 1
    gamma-aminobutyric acid type A receptor alpha1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260932.1 → NP_001247861.1  gamma-aminobutyric acid receptor subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_001247861.1

      Status: PROVISIONAL

      Source sequence(s)
      JU320578
      UniProtKB/TrEMBL
      A0A1D5QI38, A0A1D5QL80, A0A8J8YB45, F6VPP3, G7MVU2
      Related
      ENSMMUP00000064471.1, ENSMMUT00000106868.1
      Conserved Domains (2) summary
      TIGR00860
      Location:14 → 442
      LIC; Cation transporter family protein
      cd19034
      Location:56 → 249
      LGIC_ECD_GABAAR_A1; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-1 (GABAAR-A1 or GABRA1)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      159259664..159315700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141354.2 → XP_014996840.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QI38, A0A1D5QL80, A0A8J8YB45, F6VPP3, G7MVU2
      Conserved Domains (2) summary
      TIGR00860
      Location:14 → 442
      LIC; Cation transporter family protein
      cd19034
      Location:56 → 249
      LGIC_ECD_GABAAR_A1; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-1 (GABAAR-A1 or GABRA1)

    2. XM_028849020.1 → XP_028704853.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QI38, A0A1D5QL80, A0A8J8YB45, F6VPP3, G7MVU2
      Related
      ENSMMUP00000080601.1, ENSMMUT00000087176.1
      Conserved Domains (2) summary
      TIGR00860
      Location:14 → 442
      LIC; Cation transporter family protein
      cd19034
      Location:56 → 249
      LGIC_ECD_GABAAR_A1; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-1 (GABAAR-A1 or GABRA1)

    3. XM_028849019.1 → XP_028704852.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QI38
      Conserved Domains (2) summary
      TIGR00860
      Location:48 → 476
      LIC; Cation transporter family protein
      cd19034
      Location:90 → 283
      LGIC_ECD_GABAAR_A1; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-1 (GABAAR-A1 or GABRA1)

    4. XM_028849021.1 → XP_028704854.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5QI38, A0A1D5QL80, A0A8J8YB45, F6VPP3, G7MVU2
      Related
      ENSMMUP00000048805.2, ENSMMUT00000056858.2
      Conserved Domains (2) summary
      TIGR00860
      Location:14 → 442
      LIC; Cation transporter family protein
      cd19034
      Location:56 → 249
      LGIC_ECD_GABAAR_A1; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-1 (GABAAR-A1 or GABRA1)
    Nucleotide Protein
    Heading Accession and Version

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