U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HTR2A 5-hydroxytryptamine receptor 2A [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 613032, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HTR2Aprovided by VGNC
    Official Full Name
    5-hydroxytryptamine receptor 2Aprovided by VGNC
    Primary source
    VGNC:VGNC:73539
    Locus tag
    EGK_09307
    See related
    Ensembl:ENSMMUG00000004210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HTR2A in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 17 NC_041770.1 (25277017..25342367, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 17 NC_027909.1 (25989384..26054986, complement)

    Chromosome 17 - NC_041770.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 1 Neighboring gene esterase D Neighboring gene uncharacterized LOC114673514 Neighboring gene uncharacterized LOC106994257

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of [(11)C]Cimbi-36 as an agonist PET radioligand for the 5-HT(2A) and 5-HT(2C) receptors in the nonhuman primate brain. Finnema SJ, et al. Neuroimage, 2014 Jan 1. PMID 23994452
    2. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Watakabe A, et al. Cereb Cortex, 2009 Aug. PMID 19056862, Free PMC Article
    3. Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence. Johnson MP, et al. Biochim Biophys Acta, 1995 May 24. PMID 7794950
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cimbi-36 is the first agonist radioligand suitable for examination of 5-HT2A receptors in the cortical regions and of 5-HT2C receptors in the choroid plexus of the primate brain.
      Title: Characterization of [(11)C]Cimbi-36 as an agonist PET radioligand for the 5-HT(2A) and 5-HT(2C) receptors in the nonhuman primate brain.
    2. found enrichment of serotonin receptor 2A mRNA in primary visual cortex (V1) and clear activity-dependent modulatory effects of 5-HT2A receptor agonists on responses of V1 neurons.
      Title: Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    5-hydroxytryptamine receptor 2A
    Names
    5-HT-2
    5-HT-2A
    5-HT2A receptor
    serotonin receptor 2A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032966.1 → NP_001028138.1  5-hydroxytryptamine receptor 2A

      See identical proteins and their annotated locations for NP_001028138.1

      Status: PROVISIONAL

      Source sequence(s)
      S78209
      UniProtKB/Swiss-Prot
      P50128
      Related
      ENSMMUP00000036319.2, ENSMMUT00000043322.3
      Conserved Domains (1) summary
      cd15304
      Location:75 → 391
      7tmA_5-HT2A; serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041770.1 Reference Mmul_10 Primary Assembly

      Range
      25277017..25342367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015120878.2 → XP_014976364.1  5-hydroxytryptamine receptor 2A isoform X2

      Conserved Domains (1) summary
      pfam00001
      Location:54 → 296
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_015120877.2 → XP_014976363.2  5-hydroxytryptamine receptor 2A isoform X1

      UniProtKB/Swiss-Prot
      P50128
      Conserved Domains (1) summary
      cd15304
      Location:75 → 391
      7tmA_5-HT2A; serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50128.1 GenPept UniProtKB/Swiss-Prot:P50128

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials