SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SOS2provided by VGNC
Official Full Name: SOS Ras/Rho guanine nucleotide exchange factor 2provided by VGNC
Primary source: VGNC:VGNC:77838
See related: Ensembl:ENSMMUG00000007464
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	7	NC_041760.1 (112325415..112438613, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	7	NC_027899.1 (112128084..112241794, complement)

Chromosome 7 - NC_041760.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D13S1686 (e-PCR)
- UniSTS:80780

D14S166 (e-PCR)
- UniSTS:148390

G35441 (e-PCR)
- UniSTS:19369

WI-16425 (e-PCR)
- UniSTS:14518

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: son of sevenless homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001260585.1 → NP_001247514.1 son of sevenless homolog 2

See identical proteins and their annotated locations for NP_001247514.1

Status: PROVISIONAL

Source sequence(s)

JU336053

UniProtKB/TrEMBL

H9FYU7, H9ZCQ2

Related

ENSMMUP00000046283.2, ENSMMUT00000073733.2

Conserved Domains (7) summary

smart00229
Location:595 → 739

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:774 → 1013

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

cd00160
Location:199 → 386

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01261
Location:437 → 543

PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain

pfam00125
Location:63 → 169

Histone; Core histone H2A/H2B/H3/H4

pfam00169
Location:443 → 544

PH; PH domain

cl23907
Location:97 → 147

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...