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    TMPRSS6 transmembrane serine protease 6 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 696094, updated on 17-Aug-2024

    Summary

    Official Symbol
    TMPRSS6provided by VGNC
    Official Full Name
    transmembrane serine protease 6provided by VGNC
    Primary source
    VGNC:VGNC:79038
    See related
    Ensembl:ENSMMUG00000000151
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
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    Genomic context

    See TMPRSS6 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (14462831..14502225)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (79047032..79086388, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 6 Neighboring gene interleukin 2 receptor subunit beta Neighboring gene uncharacterized LOC107000657 Neighboring gene potassium channel tetramerization domain containing 17 Neighboring gene mercaptopyruvate sulfurtransferase

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane protease serine 6
    Names
    transmembrane protease, serine 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      14462831..14502225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015150283.2XP_015005769.2  transmembrane protease serine 6

      UniProtKB/TrEMBL
      F7HLZ8
      Related
      ENSMMUP00000000208.4, ENSMMUT00000000221.4
      Conserved Domains (5) summary
      cd00041
      Location:324438
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:520555
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:566798
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:480514
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam01390
      Location:75175
      SEA; SEA domain
    2. XM_015150284.2XP_015005770.2  transmembrane protease serine 6

      UniProtKB/TrEMBL
      F7HLZ8
      Conserved Domains (5) summary
      cd00041
      Location:324438
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:520555
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:566798
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:480514
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam01390
      Location:75175
      SEA; SEA domain
    3. XM_001085203.4XP_001085203.2  transmembrane protease serine 6

      UniProtKB/TrEMBL
      F7HLZ8
      Conserved Domains (5) summary
      cd00041
      Location:324438
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:520555
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:566798
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00057
      Location:480514
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam01390
      Location:75175
      SEA; SEA domain