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    NTRK3 neurotrophic receptor tyrosine kinase 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 697615, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NTRK3provided by VGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 3provided by VGNC
    Primary source
    VGNC:VGNC:75542
    See related
    Ensembl:ENSMMUG00000001386
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NTRK3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (66645145..67034967, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (65886665..66272979, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC106999276 Neighboring gene uncharacterized LOC114679266 Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene mitochondrial ribosomal protein S11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates. Fox AS, et al. Biol Psychiatry, 2019 Dec 15. PMID 31422797, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.
      Title: Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotrophin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotrophin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NT-3 growth factor receptor
    NP_001252566.1
    XP_014998420.1
    XP_014998421.1
    XP_014998422.1
    XP_028706055.1
    XP_028706056.1
    XP_028706057.1
    XP_028706058.1
    XP_028706059.1
    XP_028706060.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265637.1 → NP_001252566.1  NT-3 growth factor receptor precursor

      See identical proteins and their annotated locations for NP_001252566.1

      Status: PROVISIONAL

      Source sequence(s)
      JV667233
      UniProtKB/TrEMBL
      F7D0R9, G7MYR2, I2CY61
      Related
      ENSMMUP00000001849.4, ENSMMUT00000001962.4
      Conserved Domains (7) summary
      cd05094
      Location:532 → 818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214 → 299
      ig; Immunoglobulin domain
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218 → 221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304 → 396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      66645145..67034967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142935.2 → XP_014998421.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      G7MYR2
      Conserved Domains (7) summary
      cd05094
      Location:524 → 810
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214 → 299
      ig; Immunoglobulin domain
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218 → 221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304 → 396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    2. XM_028850223.1 → XP_028706056.1  NT-3 growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A1D5QNZ5, G7MYR2
      Related
      ENSMMUP00000049772.2, ENSMMUT00000061771.2
      Conserved Domains (7) summary
      cd05094
      Location:524 → 835
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214 → 299
      ig; Immunoglobulin domain
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218 → 221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304 → 396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    3. XM_015142934.2 → XP_014998420.1  NT-3 growth factor receptor isoform X3

      UniProtKB/TrEMBL
      G7MYR2
      Conserved Domains (7) summary
      cd05094
      Location:532 → 832
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214 → 299
      ig; Immunoglobulin domain
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218 → 221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304 → 396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    4. XM_028850222.1 → XP_028706055.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A1D5QHC7, G7MYR2
      Related
      ENSMMUP00000047448.1, ENSMMUT00000072071.2
      Conserved Domains (7) summary
      cd05094
      Location:532 → 843
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214 → 299
      ig; Immunoglobulin domain
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218 → 221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304 → 396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    5. XM_028850227.1 → XP_028706060.1  NT-3 growth factor receptor isoform X9

      UniProtKB/TrEMBL
      G7MYR2
      Conserved Domains (6) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05094
      Location:532 → 857
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat

    6. XM_028850224.1 → XP_028706057.1  NT-3 growth factor receptor isoform X5

      UniProtKB/TrEMBL
      H9F0W5
      Conserved Domains (7) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      cl21453
      Location:532 → 713
      PKc_like; Protein Kinases, catalytic domain

    7. XM_028850225.1 → XP_028706058.1  NT-3 growth factor receptor isoform X6

      UniProtKB/TrEMBL
      H9F0W5
      Conserved Domains (7) summary
      cd04971
      Location:319 → 396
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:211 → 301
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00013
      Location:31 → 56
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      pfam13855
      Location:104 → 160
      LRR_8; Leucine rich repeat
      cl21453
      Location:532 → 630
      PKc_like; Protein Kinases, catalytic domain

    8. XM_028850226.1 → XP_028706059.1  NT-3 growth factor receptor isoform X8

      UniProtKB/TrEMBL
      F7D0E6
      Conserved Domains (7) summary
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214 → 299
      ig; Immunoglobulin domain
      pfam01462
      Location:31 → 51
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218 → 221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304 → 396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    9. XM_015142936.2 → XP_014998422.1  NT-3 growth factor receptor isoform X7

      UniProtKB/TrEMBL
      F7D0C9, F7D0E6, H9FUZ7
      Related
      ENSMMUP00000001852.3, ENSMMUT00000001965.3
      Conserved Domains (7) summary
      sd00031
      Location:105 → 128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214 → 299
      ig; Immunoglobulin domain
      pfam01462
      Location:31 → 51
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103 → 160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163 → 208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218 → 221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304 → 396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    Nucleotide Protein
    Heading Accession and Version

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