MCF2L MCF.2 cell line derived transforming sequence like [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: MCF2Lprovided by VGNC
Official Full Name: MCF.2 cell line derived transforming sequence likeprovided by VGNC
Primary source: VGNC:VGNC:106270
See related: Ensembl:ENSMMUG00000048566
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 17

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	17	NC_041770.1 (94135360..94342974)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	17	NC_027909.1 (94372249..94577232)

Chromosome 17 - NC_041770.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

REN18241 (e-PCR)
- UniSTS:343041

ECD02039 (e-PCR)
- UniSTS:283140

ECD02040 (e-PCR)
- UniSTS:283141

REN18247 (e-PCR)
- UniSTS:343047

REN18248 (e-PCR)
- UniSTS:343048

REN18251 (e-PCR)
- UniSTS:343051

REN17999 (e-PCR)
- UniSTS:342799

ECD12109 (e-PCR)
- UniSTS:293142

REN18008 (e-PCR)
- UniSTS:342808

REN18265 (e-PCR)
- UniSTS:343065

REN18266 (e-PCR)
- UniSTS:343066

ECD09801 (e-PCR)
- UniSTS:290842

ECD09033 (e-PCR)
- UniSTS:290079

ECD05946 (e-PCR)
- UniSTS:287008

ECD09292 (e-PCR)
- UniSTS:290336

ECD02076 (e-PCR)
- UniSTS:283177

ECD00533 (e-PCR)
- UniSTS:281644

ECD01306 (e-PCR)
- UniSTS:282412

ECD14963 (e-PCR)
- UniSTS:295980

REN18029 (e-PCR)
- UniSTS:342829

REN18030 (e-PCR)
- UniSTS:342830

REN18031 (e-PCR)
- UniSTS:342831

ECD04934 (e-PCR)
- UniSTS:286004

REN18295 (e-PCR)
- UniSTS:343095

REN18042 (e-PCR)
- UniSTS:342842

REN18045 (e-PCR)
- UniSTS:342845

ECD10870 (e-PCR)
- UniSTS:291909

ECD09077 (e-PCR)
- UniSTS:290123

ECD06514 (e-PCR)
- UniSTS:287574

REN18327 (e-PCR)
- UniSTS:343127

REN18072 (e-PCR)
- UniSTS:342872

REN18076 (e-PCR)
- UniSTS:342876

ECD03426 (e-PCR)
- UniSTS:284508

REN17821 (e-PCR)
- UniSTS:342621

REN18077 (e-PCR)
- UniSTS:342877

REN18078 (e-PCR)
- UniSTS:342878

REN18079 (e-PCR)
- UniSTS:342879

REN18337 (e-PCR)
- UniSTS:343137

REN17826 (e-PCR)
- UniSTS:342626

REN18338 (e-PCR)
- UniSTS:343138

REN18339 (e-PCR)
- UniSTS:343139

REN17829 (e-PCR)
- UniSTS:342629

REN18341 (e-PCR)
- UniSTS:343141

REN17832 (e-PCR)
- UniSTS:342632

ECD10905 (e-PCR)
- UniSTS:291944

REN17833 (e-PCR)
- UniSTS:342633

ECD00336 (e-PCR)
- UniSTS:281449

REN17835 (e-PCR)
- UniSTS:342635

REN18092 (e-PCR)
- UniSTS:342892

REN18096 (e-PCR)
- UniSTS:342896

REN18352 (e-PCR)
- UniSTS:343152

REN18100 (e-PCR)
- UniSTS:342900

ECD14522 (e-PCR)
- UniSTS:295542

ECD23518 (e-PCR)
- UniSTS:304502

REN18359 (e-PCR)
- UniSTS:343159

REN17849 (e-PCR)
- UniSTS:342649

REN17850 (e-PCR)
- UniSTS:342650

REN18106 (e-PCR)
- UniSTS:342906

REN18363 (e-PCR)
- UniSTS:343163

REN17852 (e-PCR)
- UniSTS:342652

ECD04230 (e-PCR)
- UniSTS:285308

REN18368 (e-PCR)
- UniSTS:343168

REN18369 (e-PCR)
- UniSTS:343169

REN18372 (e-PCR)
- UniSTS:343172

REN18373 (e-PCR)
- UniSTS:343173

REN17869 (e-PCR)
- UniSTS:342669

REN17871 (e-PCR)
- UniSTS:342671

REN17873 (e-PCR)
- UniSTS:342673

stSG621865 (e-PCR)
- UniSTS:454546

ECD07867 (e-PCR)
- UniSTS:288917

REN17878 (e-PCR)
- UniSTS:342678

REN18135 (e-PCR)
- UniSTS:342935

REN18136 (e-PCR)
- UniSTS:342936

REN18137 (e-PCR)
- UniSTS:342937

stSG621872 (e-PCR)
- UniSTS:454553

stSG621873 (e-PCR)
- UniSTS:454554

REN17884 (e-PCR)
- UniSTS:342684

REN18140 (e-PCR)
- UniSTS:342940

REN17885 (e-PCR)
- UniSTS:342685

REN17887 (e-PCR)
- UniSTS:342687

REN17888 (e-PCR)
- UniSTS:342688

ECD15083 (e-PCR)
- UniSTS:296100

stSG621883 (e-PCR)
- UniSTS:454564

stSG621884 (e-PCR)
- UniSTS:454565

REN18151 (e-PCR)
- UniSTS:342951

stSG621887 (e-PCR)
- UniSTS:454568

stSG621889 (e-PCR)
- UniSTS:454570

stSG621892 (e-PCR)
- UniSTS:454573

REN18162 (e-PCR)
- UniSTS:342962

ECD05320 (e-PCR)
- UniSTS:286386

REN17907 (e-PCR)
- UniSTS:342707

stSG621900 (e-PCR)
- UniSTS:454581

stSG621901 (e-PCR)
- UniSTS:454582

stSG621902 (e-PCR)
- UniSTS:454583

stSG621903 (e-PCR)
- UniSTS:454584

stSG621904 (e-PCR)
- UniSTS:454585

stSG621905 (e-PCR)
- UniSTS:454586

REN18171 (e-PCR)
- UniSTS:342971

ECD01710 (e-PCR)
- UniSTS:282811

REN18172 (e-PCR)
- UniSTS:342972

REN18173 (e-PCR)
- UniSTS:342973

REN18174 (e-PCR)
- UniSTS:342974

REN17922 (e-PCR)
- UniSTS:342722

REN17924 (e-PCR)
- UniSTS:342724

REN17926 (e-PCR)
- UniSTS:342726

REN18184 (e-PCR)
- UniSTS:342984

REN17938 (e-PCR)
- UniSTS:342738

REN18201 (e-PCR)
- UniSTS:343001

ECD00193 (e-PCR)
- UniSTS:281307

REN17948 (e-PCR)
- UniSTS:342748

REN17952 (e-PCR)
- UniSTS:342752

REN17953 (e-PCR)
- UniSTS:342753

REN17954 (e-PCR)
- UniSTS:342754

REN17955 (e-PCR)
- UniSTS:342755

REN17956 (e-PCR)
- UniSTS:342756

REN17964 (e-PCR)
- UniSTS:342764

REN18222 (e-PCR)
- UniSTS:343022

REN17967 (e-PCR)
- UniSTS:342767

REN17968 (e-PCR)
- UniSTS:342768

REN18225 (e-PCR)
- UniSTS:343025

REN17971 (e-PCR)
- UniSTS:342771

REN17972 (e-PCR)
- UniSTS:342772

REN18232 (e-PCR)
- UniSTS:343032

ECD11824 (e-PCR)
- UniSTS:292858

REN18236 (e-PCR)
- UniSTS:343036

REN18237 (e-PCR)
- UniSTS:343037

ECD01001 (e-PCR)
- UniSTS:282110

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extrinsic component of membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: guanine nucleotide exchange factor DBS

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041770.1 Reference Mmul_10 Primary Assembly

Range

94135360..94342974

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015121478.2 → XP_014976964.2 guanine nucleotide exchange factor DBS isoform X8

UniProtKB/TrEMBL

A0A5F8A2J9

Related

ENSMMUP00000045635.2, ENSMMUT00000069845.2

Conserved Domains (5) summary

cd11857
Location:1119 → 1172

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:74 → 219

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:630 → 813

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:350 → 537

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:820 → 951

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837346.1 → XP_028693179.1 guanine nucleotide exchange factor DBS isoform X1

UniProtKB/TrEMBL

G7NJN1

Conserved Domains (5) summary

cd11857
Location:1184 → 1237

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:139 → 284

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:695 → 878

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:415 → 626

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:885 → 1016

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837348.1 → XP_028693181.1 guanine nucleotide exchange factor DBS isoform X3

UniProtKB/TrEMBL

G7NJN1

Conserved Domains (5) summary

cd11857
Location:1153 → 1206

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:139 → 284

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:695 → 878

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:415 → 626

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:885 → 1016

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837351.1 → XP_028693184.1 guanine nucleotide exchange factor DBS isoform X6

UniProtKB/TrEMBL

G7NJN1

Conserved Domains (5) summary

cd11857
Location:1128 → 1181

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:139 → 284

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:695 → 878

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:415 → 626

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:885 → 1016

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837347.1 → XP_028693180.1 guanine nucleotide exchange factor DBS isoform X2

UniProtKB/TrEMBL

G7NJN1

Conserved Domains (5) summary

cd11857
Location:1178 → 1231

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:139 → 284

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:695 → 872

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:415 → 626

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:879 → 1010

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837349.1 → XP_028693182.1 guanine nucleotide exchange factor DBS isoform X4

UniProtKB/TrEMBL

G7NJN1

Conserved Domains (5) summary

cd11857
Location:1147 → 1200

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:139 → 284

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:695 → 872

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:415 → 626

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:879 → 1010

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837352.1 → XP_028693185.1 guanine nucleotide exchange factor DBS isoform X7

UniProtKB/TrEMBL

G7NJN1

Conserved Domains (5) summary

cd11857
Location:1122 → 1175

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:139 → 284

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:695 → 872

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:415 → 626

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:879 → 1010

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837350.1 → XP_028693183.1 guanine nucleotide exchange factor DBS isoform X5

UniProtKB/TrEMBL

G7NJN1

Conserved Domains (5) summary

cd11857
Location:1144 → 1197

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

cd00160
Location:655 → 838

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:375 → 586

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:845 → 976

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

cl15787
Location:139 → 244

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
XM_015121481.2 → XP_014976967.2 guanine nucleotide exchange factor DBS isoform X10

UniProtKB/TrEMBL

A0A5F8AEH0

Conserved Domains (5) summary

cd11857
Location:1091 → 1144

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:46 → 191

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:602 → 785

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:322 → 509

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:792 → 923

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121484.2 → XP_014976970.2 guanine nucleotide exchange factor DBS isoform X12

UniProtKB/TrEMBL

A0A5F8AEH0

Conserved Domains (5) summary

cd11857
Location:1085 → 1138

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:46 → 191

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:602 → 779

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:322 → 509

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:786 → 917

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121493.2 → XP_014976979.2 guanine nucleotide exchange factor DBS isoform X17

UniProtKB/TrEMBL

H9F639

Related

ENSMMUP00000076091.1, ENSMMUT00000080345.1

Conserved Domains (5) summary

cd11857
Location:1029 → 1082

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:46 → 191

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:602 → 779

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:322 → 509

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:786 → 917

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121488.2 → XP_014976974.2 guanine nucleotide exchange factor DBS isoform X14

UniProtKB/TrEMBL

A0A5F8AEH0

Related

ENSMMUP00000075782.1, ENSMMUT00000095728.1

Conserved Domains (5) summary

cd11857
Location:1062 → 1115

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:17 → 162

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:573 → 756

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:293 → 480

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:763 → 894

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121487.2 → XP_014976973.2 guanine nucleotide exchange factor DBS isoform X14

UniProtKB/TrEMBL

A0A5F8AEH0

Conserved Domains (5) summary

cd11857
Location:1062 → 1115

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:17 → 162

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:573 → 756

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:293 → 480

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:763 → 894

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121480.2 → XP_014976966.2 guanine nucleotide exchange factor DBS isoform X9

UniProtKB/TrEMBL

A0A5F7ZAM5

Related

ENSMMUP00000062648.1, ENSMMUT00000089569.1

Conserved Domains (5) summary

cd11857
Location:1095 → 1148

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:50 → 195

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:606 → 789

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:326 → 513

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:796 → 927

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121495.2 → XP_014976981.2 guanine nucleotide exchange factor DBS isoform X21

UniProtKB/TrEMBL

A0A5F7ZAM5

Conserved Domains (5) summary

smart00516
Location:50 → 195

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:606 → 783

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:326 → 513

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:790 → 921

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

cl17036
Location:1033 → 1067

SH3; Src Homology 3 domain superfamily
XM_015121485.2 → XP_014976971.2 guanine nucleotide exchange factor DBS isoform X13

UniProtKB/TrEMBL

A0A5F8AEH0

Conserved Domains (5) summary

cd11857
Location:1083 → 1136

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:44 → 189

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:600 → 777

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:320 → 507

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:784 → 915

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121494.2 → XP_014976980.2 guanine nucleotide exchange factor DBS isoform X18

UniProtKB/TrEMBL

A0A1D5R1Z2

Related

ENSMMUP00000054326.2, ENSMMUT00000054367.2

Conserved Domains (5) summary

cd11857
Location:1027 → 1080

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:44 → 189

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:600 → 777

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:320 → 507

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:784 → 915

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121482.2 → XP_014976968.2 guanine nucleotide exchange factor DBS isoform X11

UniProtKB/TrEMBL

A0A5F8AEH0

Conserved Domains (5) summary

cd11857
Location:1089 → 1142

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:44 → 189

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:600 → 783

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:320 → 507

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:790 → 921

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121491.2 → XP_014976977.2 guanine nucleotide exchange factor DBS isoform X15

UniProtKB/TrEMBL

A0A5F8AEH0

Conserved Domains (5) summary

cd11857
Location:1053 → 1106

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:62 → 153

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:564 → 747

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:284 → 471

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:754 → 885

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_015121492.2 → XP_014976978.2 guanine nucleotide exchange factor DBS isoform X16

UniProtKB/TrEMBL

A0A5F8AEH0

Conserved Domains (5) summary

cd11857
Location:1047 → 1100

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:62 → 153

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:564 → 741

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:284 → 471

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:748 → 879

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837353.1 → XP_028693186.1 guanine nucleotide exchange factor DBS isoform X19

UniProtKB/TrEMBL

A0A1D5R1Z2, A0A5F7ZQD1

Related

ENSMMUP00000067358.1, ENSMMUT00000108339.1

Conserved Domains (5) summary

cd11857
Location:1016 → 1069

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:62 → 153

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:564 → 741

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:284 → 471

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:748 → 879

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
XM_028837354.1 → XP_028693187.1 guanine nucleotide exchange factor DBS isoform X20

UniProtKB/TrEMBL

H9F639

Conserved Domains (5) summary

cd11857
Location:991 → 1044

SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor

smart00516
Location:62 → 153

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

cd00160
Location:564 → 741

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd00176
Location:284 → 471

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd01227
Location:748 → 879

PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain