SELENOI selenoprotein I [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SELENOIprovided by VGNC
Official Full Name: selenoprotein Iprovided by VGNC
Primary source: VGNC:VGNC:77335
See related: Ensembl:ENSMMUG00000014287
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: EPT1; SELI
Summary: The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	13	NC_041766.1 (82582472..82631410, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	13	NC_027905.1 (26612615..26661866)

Chromosome 13 - NC_041766.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-24366 (e-PCR)
- UniSTS:99863

RH102210 (e-PCR)
- UniSTS:96544

RH98632 (e-PCR)
- UniSTS:87780

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ethanolaminephosphotransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ethanolaminephosphotransferase 1

Names: ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

NP_001129035.1

EC 2.7.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135563.3 → NP_001129035.1 ethanolaminephosphotransferase 1

Status: REVIEWED

Source sequence(s)

QNVO02000093

UniProtKB/TrEMBL

A0A1D5Q035

Related

ENSMMUP00000018765.3, ENSMMUT00000020049.4

Conserved Domains (1) summary

cl00453
Location:6 → 382

CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase