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    REL REL proto-oncogene, NF-kB subunit [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717804, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RELprovided by VGNC
    Official Full Name
    REL proto-oncogene, NF-kB subunitprovided by VGNC
    Primary source
    VGNC:VGNC:76892
    See related
    Ensembl:ENSMMUG00000010834
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See REL in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (47895092..47937123, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (61677576..61720216)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene pseudouridine synthase 10 Neighboring gene non-POU domain-containing octamer-binding protein pseudogene Neighboring gene 40S ribosomal protein S12 pseudogene Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC106992976 Neighboring gene poly(A) polymerase gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene c-Rel
    Names
    v-rel reticuloendotheliosis viral oncogene homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      47895092..47937123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015112447.2 → XP_014967933.1  proto-oncogene c-Rel isoform X2

      UniProtKB/TrEMBL
      A0A5F8AAA9, F7GNW3
      Related
      ENSMMUP00000074878.1, ENSMMUT00000086944.1
      Conserved Domains (2) summary
      cd07933
      Location:8 → 179
      RHD-n_c-Rel; N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel
      cd01177
      Location:186 → 281
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

    2. XM_002799234.3 → XP_002799280.1  proto-oncogene c-Rel isoform X1

      UniProtKB/TrEMBL
      A0A1D5R4I0, F7GNW3
      Related
      ENSMMUP00000055216.1, ENSMMUT00000076564.2
      Conserved Domains (2) summary
      cd07933
      Location:8 → 179
      RHD-n_c-Rel; N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel
      pfam16179
      Location:187 → 282
      RHD_dimer; Rel homology dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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