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    BECN1 beclin 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 711649, updated on 17-Aug-2024

    Summary

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    Official Symbol
    BECN1provided by VGNC
    Official Full Name
    beclin 1provided by VGNC
    Primary source
    VGNC:VGNC:70044
    See related
    Ensembl:ENSMMUG00000029971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    beclin-1
    Orthologs
    human mouse all
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    Genomic context

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    See BECN1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (53942168..53955701, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (48667464..48681776, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene coiled-coil domain containing 56 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene proteasome activator subunit 3 Neighboring gene amine oxidase copper containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging. Guo R, et al. Nat Struct Mol Biol, 2024 Feb. PMID 38177673
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.
      Title: Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type I IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III, type II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beclin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266685.1 → NP_001253614.1  beclin-1

      See identical proteins and their annotated locations for NP_001253614.1

      Status: PROVISIONAL

      Source sequence(s)
      JV043436
      UniProtKB/TrEMBL
      G7NIN4, H9YW59
      Conserved Domains (3) summary
      pfam04111
      Location:264 → 445
      APG6; Autophagy protein Apg6
      pfam15285
      Location:107 → 129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam17675
      Location:135 → 261
      APG6_N; Apg6 coiled-coil region

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      53942168..53955701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015119739.2 → XP_014975225.1  beclin-1 isoform X2

      UniProtKB/TrEMBL
      G7NIN4, H9YW59
      Related
      ENSMMUP00000034400.3, ENSMMUT00000041372.3
      Conserved Domains (3) summary
      pfam04111
      Location:264 → 445
      APG6; Autophagy protein Apg6
      pfam15285
      Location:107 → 129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam17675
      Location:135 → 261
      APG6_N; Apg6 coiled-coil region

    2. XM_015119738.2 → XP_014975224.1  beclin-1 isoform X1

      UniProtKB/TrEMBL
      F6PQC7, G7NIN4
      Conserved Domains (2) summary
      pfam15285
      Location:130 → 152
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam04111
      Location:158 → 468
      APG6; Autophagy protein Apg6

    3. XM_015119743.2 → XP_014975229.1  beclin-1 isoform X4

      Conserved Domains (2) summary
      pfam15285
      Location:107 → 129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam04111
      Location:135 → 347
      APG6; Autophagy protein Apg6

    4. XM_015119740.2 → XP_014975226.1  beclin-1 isoform X3

      Conserved Domains (2) summary
      pfam15285
      Location:130 → 152
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam04111
      Location:158 → 370
      APG6; Autophagy protein Apg6

    5. XM_015119737.2 → XP_014975223.1  beclin-1 isoform X1

      UniProtKB/TrEMBL
      F6PQC7, G7NIN4
      Related
      ENSMMUP00000034399.3, ENSMMUT00000041371.3
      Conserved Domains (2) summary
      pfam15285
      Location:130 → 152
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
      pfam04111
      Location:158 → 468
      APG6; Autophagy protein Apg6
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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