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    RAPGEF6 Rap guanine nucleotide exchange factor 6 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 706541, updated on 17-Aug-2024

    Summary

    Official Symbol
    RAPGEF6provided by VGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 6provided by VGNC
    Primary source
    VGNC:VGNC:110185
    See related
    Ensembl:ENSMMUG00000006165
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
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    Genomic context

    See RAPGEF6 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (128874860..129093419, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (129116428..129335627, complement)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene LYR motif containing 7 Neighboring gene uncharacterized LOC114678900 Neighboring gene CDC42 small effector 2 Neighboring gene uncharacterized LOC106998938 Neighboring gene actin, cytoplasmic 1-like Neighboring gene folliculin interacting protein 1 Neighboring gene uncharacterized LOC114678901 Neighboring gene meiotic kinetochore factor

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RefSeq

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 6
    Names
    Rap guanine nucleotide exchange factor (GEF) 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      128874860..129093419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015140708.2XP_014996194.1  rap guanine nucleotide exchange factor 6 isoform X5

      UniProtKB/TrEMBL
      H9F6S5
      Conserved Domains (7) summary
      smart00229
      Location:378491
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:240414
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:246346
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8281052
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:495575
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:348
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:720804
      UBQ; Ubiquitin-like proteins
    2. XM_015140711.2XP_014996197.1  rap guanine nucleotide exchange factor 6 isoform X9

      UniProtKB/TrEMBL
      H9F6S5
      Conserved Domains (6) summary
      smart00229
      Location:265378
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:127301
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:133233
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:715939
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:382462
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:607691
      UBQ; Ubiquitin-like proteins
    3. XM_001101427.4XP_001101427.1  rap guanine nucleotide exchange factor 6 isoform X4

      UniProtKB/TrEMBL
      A0A5F8A3P4, H9ZA13
      Related
      ENSMMUP00000071543.1, ENSMMUT00000104766.1
      Conserved Domains (7) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:274448
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8571067
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:749833
      UBQ; Ubiquitin-like proteins
    4. XM_015140710.2XP_014996196.1  rap guanine nucleotide exchange factor 6 isoform X6

      UniProtKB/TrEMBL
      F7HR13, H9F6S5
      Related
      ENSMMUP00000008113.4, ENSMMUT00000008631.4
      Conserved Domains (6) summary
      smart00229
      Location:317430
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:179353
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:185285
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:767991
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:434514
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00155
      Location:659743
      UBQ; Ubiquitin-like proteins
    5. XM_015140707.2XP_014996193.1  rap guanine nucleotide exchange factor 6 isoform X3

      UniProtKB/TrEMBL
      H9ZA13
      Conserved Domains (7) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:274448
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8621072
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:754838
      UBQ; Ubiquitin-like proteins
    6. XM_015140706.2XP_014996192.1  rap guanine nucleotide exchange factor 6 isoform X1

      UniProtKB/TrEMBL
      F7HST4, H9ZA13
      Related
      ENSMMUP00000008111.4, ENSMMUT00000008629.4
      Conserved Domains (7) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:274448
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8621086
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:754838
      UBQ; Ubiquitin-like proteins
    7. XM_002804506.3XP_002804552.1  rap guanine nucleotide exchange factor 6 isoform X8

      See identical proteins and their annotated locations for XP_002804552.1

      UniProtKB/TrEMBL
      H9F7F1
      Conserved Domains (7) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:274448
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8571081
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:749833
      UBQ; Ubiquitin-like proteins
    8. XM_001101236.4XP_001101236.2  rap guanine nucleotide exchange factor 6 isoform X2

      UniProtKB/TrEMBL
      H9ZA13
      Related
      ENSMMUP00000067284.1, ENSMMUT00000086035.1
      Conserved Domains (7) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:274448
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8571081
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:749833
      UBQ; Ubiquitin-like proteins
    9. XM_001100970.4XP_001100970.1  rap guanine nucleotide exchange factor 6 isoform X7

      See identical proteins and their annotated locations for XP_001100970.1

      UniProtKB/TrEMBL
      F7HR15, H9F7F1
      Related
      ENSMMUP00000008112.3, ENSMMUT00000008630.4
      Conserved Domains (7) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      COG0664
      Location:274448
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8621086
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:754838
      UBQ; Ubiquitin-like proteins
    10. XM_001100863.4XP_001100863.1  rap guanine nucleotide exchange factor 6 isoform X11

      See identical proteins and their annotated locations for XP_001100863.1

      UniProtKB/TrEMBL
      H9F7F1
      Conserved Domains (6) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8571067
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:749833
      UBQ; Ubiquitin-like proteins
    11. XM_015140712.2XP_014996198.1  rap guanine nucleotide exchange factor 6 isoform X10

      UniProtKB/TrEMBL
      H9F7F1
      Conserved Domains (6) summary
      smart00229
      Location:412525
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:280380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:8571081
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:529609
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00047
      Location:3782
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl00155
      Location:749833
      UBQ; Ubiquitin-like proteins
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