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    LCA5 lebercilin LCA5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 716999, updated on 17-Aug-2024

    Summary

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    Official Symbol
    LCA5provided by VGNC
    Official Full Name
    lebercilin LCA5provided by VGNC
    Primary source
    VGNC:VGNC:74172
    Locus tag
    EGK_15103
    See related
    Ensembl:ENSMMUG00000004356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    Lebercilin
    Orthologs
    human mouse all
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    Genomic context

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    See LCA5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (93527728..93581471)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (77696975..77750421, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene protein S100-A11 Neighboring gene SH3 domain binding glutamate rich protein like 2 Neighboring gene acyl-CoA-binding protein pseudogene Neighboring gene ADP/ATP translocase 2-like Neighboring gene dnaJ homolog subfamily B member 6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in intraciliary transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lebercilin
    Names
    LCA5, lebercilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266344.1 → NP_001253273.1  lebercilin

      See identical proteins and their annotated locations for NP_001253273.1

      Status: PROVISIONAL

      Source sequence(s)
      JU333211
      UniProtKB/TrEMBL
      A0A8J8XRT6, F7FVD2, G7MPS6, H9FQQ7
      Related
      ENSMMUP00000066303.1, ENSMMUT00000104291.1
      Conserved Domains (2) summary
      pfam15619
      Location:107 → 286
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl14813
      Location:149 → 285
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      93527728..93581471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028846849.1 → XP_028702682.1  lebercilin isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZKZ3, F7FVD2
      Conserved Domains (2) summary
      COG0419
      Location:105 → 485
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15619
      Location:107 → 286
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

    2. XM_015136780.2 → XP_014992266.2  lebercilin isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZKZ3, F7FVD2
      Conserved Domains (2) summary
      COG0419
      Location:105 → 485
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15619
      Location:107 → 286
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

    3. XM_015136783.2 → XP_014992269.2  lebercilin isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZKZ3, F7FVD2
      Conserved Domains (2) summary
      COG0419
      Location:105 → 485
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15619
      Location:107 → 286
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

    4. XM_015136779.2 → XP_014992265.2  lebercilin isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZKZ3, F7FVD2
      Related
      ENSMMUP00000005827.4, ENSMMUT00000006191.4
      Conserved Domains (2) summary
      COG0419
      Location:105 → 485
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15619
      Location:107 → 286
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

    5. XM_028846850.1 → XP_028702683.1  lebercilin isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZKZ3, F7FVD2
      Conserved Domains (2) summary
      COG0419
      Location:105 → 485
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15619
      Location:107 → 286
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    Nucleotide Protein
    Heading Accession and Version

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