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    NOS3 nitric oxide synthase 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714231, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NOS3provided by VGNC
    Official Full Name
    nitric oxide synthase 3provided by VGNC
    Primary source
    VGNC:VGNC:75370
    See related
    Ensembl:ENSMMUG00000020437
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NOS3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (176995246..177016276)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (177214971..177235532)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene amine oxidase copper containing 1 Neighboring gene potassium voltage-gated channel subfamily H member 2 Neighboring gene uncharacterized LOC100424674 Neighboring gene autophagy related 9B Neighboring gene ATP binding cassette subfamily B member 8 Neighboring gene acid sensing ion channel subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nitric oxide synthase, endothelial
    Names
    nitric oxide synthase 3 (endothelial cell)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      176995246..177016276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015135287.1 → XP_014990773.1  nitric oxide synthase, endothelial isoform X1

      UniProtKB/TrEMBL
      F6WEB2, G7MNG2
      Related
      ENSMMUP00000026905.4, ENSMMUT00000028753.4
      Conserved Domains (4) summary
      COG0369
      Location:512 → 1159
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:68 → 480
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:522 → 698
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:762 → 1164
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    2. XM_028846473.1 → XP_028702306.1  nitric oxide synthase, endothelial isoform X3

      Conserved Domains (2) summary
      cd00795
      Location:68 → 480
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:522 → 593
      Flavodoxin_1

    3. XM_015135288.1 → XP_014990774.1  nitric oxide synthase, endothelial isoform X2

      UniProtKB/TrEMBL
      A0A1D5QK05
      Conserved Domains (2) summary
      cd00795
      Location:68 → 480
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:522 → 586
      Flavodoxin_1; Flavodoxin
    Nucleotide Protein
    Heading Accession and Version

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