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    PGR progesterone receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 613024, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PGRprovided by VGNC
    Official Full Name
    progesterone receptorprovided by VGNC
    Primary source
    VGNC:VGNC:75972
    See related
    Ensembl:ENSMMUG00000011846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    PR
    Orthologs
    human mouse all
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    Genomic context

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    See PGR in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (94342672..94434226, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (93965601..94057836, complement)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene contactin 5 Neighboring gene replication protein A 32 kDa subunit pseudogene Neighboring gene Rho GTPase activating protein 42 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC114672384 Neighboring gene transient receptor potential cation channel subfamily C member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production. Bishop CV, et al. Biol Reprod, 2016 May. PMID 26985003, Free PMC Article
    2. Progesterone receptor, but not estradiol receptor, messenger ribonucleic acid is expressed in luteinizing granulosa cells and the corpus luteum in rhesus monkeys. Chandrasekher YA, et al. Endocrinology, 1994 Jul. PMID 8013365
    3. Alterations in progesterone receptor membrane component 2 (PGRMC2) in the endometrium of macaques afflicted with advanced endometriosis. Keator CS, et al. Mol Hum Reprod, 2012 Jun. PMID 22307145, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in steroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    progesterone receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278456.1 → NP_001265385.1  progesterone receptor isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AANU01120146, AANU01120147, AANU01120150, HM100162, HM100163, S71038
      UniProtKB/TrEMBL
      F7H4Y4
      Related
      ENSMMUP00000015545.4, ENSMMUT00000016595.4
      Conserved Domains (3) summary
      cd07074
      Location:689 → 936
      NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor
      cd07172
      Location:566 → 643
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1 → 567
      Prog_receptor; Progesterone receptor

    2. NM_001278457.1 → NP_001265386.1  progesterone receptor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. In encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AANU01120146, AANU01120147, AANU01120150, HM100162, S71038
      UniProtKB/TrEMBL
      F6ZBA4
      Related
      ENSMMUP00000036755.3, ENSMMUT00000043766.3
      Conserved Domains (3) summary
      cd07172
      Location:566 → 642
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1 → 567
      Prog_receptor; Progesterone receptor
      cl11397
      Location:637 → 834
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      94342672..94434226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028832502.1 → XP_028688335.1  progesterone receptor isoform X1

      UniProtKB/TrEMBL
      F7H4Y4
      Conserved Domains (3) summary
      cd07172
      Location:566 → 643
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02161
      Location:1 → 567
      Prog_receptor; Progesterone receptor
      cl11397
      Location:689 → 789
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version

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