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    SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713777, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SOS1provided by VGNC
    Official Full Name
    SOS Ras/Rac guanine nucleotide exchange factor 1provided by VGNC
    Primary source
    VGNC:VGNC:77837
    See related
    Ensembl:ENSMMUG00000020575
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SOS1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 13 NC_041766.1 (69774459..69922463)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 13 NC_027905.1 (39463401..39610971, complement)

    Chromosome 13 - NC_041766.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase like 4 Neighboring gene 2-iminobutanoate/2-iminopropanoate deaminase Neighboring gene uncharacterized LOC114671734 Neighboring gene U6 spliceosomal RNA Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene U6 spliceosomal RNA Neighboring gene MORN repeat containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    son of sevenless homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041766.1 Reference Mmul_10 Primary Assembly

      Range
      69774459..69922463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028831741.1 → XP_028687574.1  son of sevenless homolog 1 isoform X1

      UniProtKB/TrEMBL
      F6SW16, F6ZRJ0
      Related
      ENSMMUP00000009792.4, ENSMMUT00000010434.4
      Conserved Domains (6) summary
      PTZ00449
      Location:1018 → 1319
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00229
      Location:597 → 741
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00325
      Location:204 → 389
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00155
      Location:776 → 1015
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd01261
      Location:439 → 545
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:63 → 169
      Histone; Core histone H2A/H2B/H3/H4

    2. XM_028831742.1 → XP_028687575.1  son of sevenless homolog 1 isoform X2

      UniProtKB/TrEMBL
      F6ZRJ0, F7D162
      Related
      ENSMMUP00000027088.4, ENSMMUT00000028947.4
      Conserved Domains (6) summary
      PTZ00449
      Location:1018 → 1304
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00229
      Location:597 → 741
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00325
      Location:204 → 389
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00155
      Location:776 → 1015
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd01261
      Location:439 → 545
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:63 → 169
      Histone; Core histone H2A/H2B/H3/H4
    Nucleotide Protein
    Heading Accession and Version

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