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    SHMT2 serine hydroxymethyltransferase 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714433, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SHMT2provided by VGNC
    Official Full Name
    serine hydroxymethyltransferase 2provided by VGNC
    Primary source
    VGNC:VGNC:77211
    Locus tag
    EGK_03829
    See related
    Ensembl:ENSMMUG00000021785
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See SHMT2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (56795837..56801444)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (56014333..56019945)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 1 Neighboring gene uncharacterized LOC114671100 Neighboring gene neurexophilin 4 Neighboring gene NDUFA4 mitochondrial complex associated like 2 Neighboring gene uncharacterized LOC107000896 Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene R3H domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cobalt ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA 5'-UTR binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in folic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in purine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to type I interferon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BRISC complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine hydroxymethyltransferase, mitochondrial
    XP_015007584.1
    XP_015007585.1
    XP_015007586.1
    XP_015007587.1
    XP_015007588.1
    XP_015007590.1
    XP_015007591.1
    XP_015007592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      56795837..56801444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015152100.2 → XP_015007586.1  serine hydroxymethyltransferase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A1D5Q4D6, H9ES01
      Related
      ENSMMUP00000053052.1, ENSMMUT00000077277.2
      Conserved Domains (1) summary
      PLN03226
      Location:45 → 502
      PLN03226; serine hydroxymethyltransferase; Provisional

    2. XM_015152099.2 → XP_015007585.1  serine hydroxymethyltransferase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZWZ7
      Related
      ENSMMUP00000069693.1, ENSMMUT00000106196.1
      Conserved Domains (2) summary
      PLN03226
      Location:106 → 504
      PLN03226; serine hydroxymethyltransferase; Provisional
      cl18945
      Location:105 → 450
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    3. XM_015152105.2 → XP_015007591.1  serine hydroxymethyltransferase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZEZ7
      Related
      ENSMMUP00000077746.1, ENSMMUT00000102751.1
      Conserved Domains (1) summary
      cl18945
      Location:101 → 406
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    4. XM_015152102.2 → XP_015007588.1  serine hydroxymethyltransferase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZEZ7
      Related
      ENSMMUP00000063186.1, ENSMMUT00000107647.1
      Conserved Domains (1) summary
      cl18945
      Location:101 → 406
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    5. XM_015152098.2 → XP_015007584.1  serine hydroxymethyltransferase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q1X8, A0A5S6R9G2, A0A8J8Y9U0, G7N7F2
      Related
      ENSMMUP00000042040.2, ENSMMUT00000072162.2
      Conserved Domains (2) summary
      PLN03226
      Location:113 → 511
      PLN03226; serine hydroxymethyltransferase; Provisional
      cl18945
      Location:112 → 457
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    6. XM_015152104.2 → XP_015007590.1  serine hydroxymethyltransferase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZEZ7
      Conserved Domains (1) summary
      cl18945
      Location:101 → 406
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    7. XM_015152101.2 → XP_015007587.1  serine hydroxymethyltransferase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      F7DED8
      Related
      ENSMMUP00000028687.4, ENSMMUT00000030652.4
      Conserved Domains (1) summary
      PLN03226
      Location:24 → 481
      PLN03226; serine hydroxymethyltransferase; Provisional

    8. XM_015152106.2 → XP_015007592.1  serine hydroxymethyltransferase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZEZ7
      Conserved Domains (1) summary
      cl18945
      Location:101 → 406
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version

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